Hair analysis for biomonitoring of environmental and occupational exposure to organic pollutants: State of the art, critical review and future needs

被引：140

作者：

Appenzeller, Brice M. R. ^{[1
]}

Tsatsakis, Aristidis M. ^{[2
]}

机构：

[1] Univ Luxembourg, Lab Analyt Human Biomonitoring CRP Sante, L-1511 Luxembourg, Luxembourg

[2] Univ Crete, Sch Med, Div Morphol, Ctr Toxicol Sci & Res, Iraklion 71003, Crete, Greece

来源：

TOXICOLOGY LETTERS | 2012年 / 210卷 / 02期

关键词：

Hair analysis; Human biomonitoring; Organic pollutants; Biomarker of exposure; POLYCYCLIC AROMATIC-HYDROCARBONS; PERSISTENT ORGANOCHLORINE POLLUTANTS; BROMINATED FLAME RETARDANTS; SOLID-PHASE MICROEXTRACTION; DETECT FETAL EXPOSURE; LONG-TERM TREATMENT; GAS-CHROMATOGRAPHY; CORD BLOOD; HEAD HAIR; POLYCHLORINATED-BIPHENYLS;

D O I：

10.1016/j.toxlet.2011.10.021

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This paper presents the current state of the art in human hair analysis for the detection of organic pollutants associated with environmental and occupational exposure. The different chemical classes are reviewed with a special focus set on compounds that were only recently investigated. The importance of methods sensitivity and particularly the influence of this parameter on the results presented in previous publications is highlighted. This report also investigates the relevance of hair analysis as an indicator of subjects' level of exposure and underlines limitations that are still associated with this matrix. This study also presents a critical assessment of some specific aspects presented in the literature as well as future needs to strengthen the position of hair as a relevant biomarker of exposure to be used in epidemiological studies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：119 / 140

页数：22

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