Microenvironment and tumor cell plasticity: An easy way out

被引：197

作者：

Taddei, Maria Letizia ^{[1
]}

Giannoni, Elisa ^{[1
]}

Comito, Giuseppina ^{[1
]}

Chiarugi, Paola ^{[1
,2
,3
]}

机构：

[1] Univ Florence, Dept Biochem Sci, I-50134 Florence, Italy

[2] Ist Toscano Tumori, I-50134 Florence, Italy

[3] Ctr Res Transfer & High Educ DenoTHE, I-50134 Florence, Italy

来源：

CANCER LETTERS | 2013年 / 341卷 / 01期

关键词：

Cell plasticity; Microenvironment; Cell motility; Hypoxia; Acidity; Extracellular matrix; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL PROGENITOR CELLS; NF-KAPPA-B; CARBONIC-ANHYDRASE IX; PROSTATE-CANCER CELLS; HYPOXIA-INDUCIBLE FACTORS; CHEMOKINE RECEPTOR CXCR4; MEDIATED DRUG-RESISTANCE; BREAST-CARCINOMA CELLS; SMOOTH MUSCLE ACTIN;

D O I：

10.1016/j.canlet.2013.01.042

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cells undergo genetic changes allowing their adaptation to environmental changes, thereby obtaining an advantage during the long metastatic route, disseminated of several changes in the surrounding environment. In particular, plasticity in cell motility, mainly due to epigenetic regulation of cancer cells by environmental insults, engage adaptive strategies aimed essentially to survive in hostile milieu, thereby escaping adverse sites. This review is focused on tumor microenvironment as a collection of structural and cellular elements promoting plasticity and adaptive programs. We analyze the role of extracellular matrix stiffness, hypoxia, nutrient deprivation, acidity, as well as different cell populations of tumor microenvironment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 96

页数：17

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