A preliminary study on investigating the attachment of soft tissue onto micro-arc oxidized titanium alloy implants

被引:23
作者
Chen, G. J. [1 ]
Wang, Z. [1 ]
Bai, H. [2 ]
Li, J. M. [3 ]
Cai, H. [4 ]
机构
[1] Fourth Mil Med Univ, Dept Orthopaed, Xijing Hosp, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Dept Toxicol, Xian 710032, Peoples R China
[3] Xian Univ Technol, Sch Mat Sci & Engn, Xian 710048, Peoples R China
[4] Xi An Jiao Tong Univ, Sch Sci, Xian 710049, Peoples R China
关键词
BONE RESPONSE; SURFACE-PROPERTIES; OXIDE FILMS; PROSTHESES; AMPUTEES; BEHAVIOR; CA; REHABILITATION; OXIDATION; INVITRO;
D O I
10.1088/1748-6041/4/1/015017
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Intraosseous transcutaneous amputation prostheses (ITAP) rely on the integrity of the soft tissue-implant interface as a barrier to exogenous agents, and in the prevention of avulsion and marsupilization. This experimental work aimed at the in vivo evaluation of soft tissue attachment to Ti alloy (Ti(6)Al(4)V) transcutaneous custom-made screws treated by a micro-arc oxidation (MAO) method. Prior to implantation, the surface of the MAO treated implants was analyzed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and x-ray diffraction (XRD). The experimental model comprised implantation of 16 transcutaneous screws (two groups: MAO and machined (control); total eight implants/group) in the medial aspect of the left tibia of eight female goats. The animals were euthanized at eight weeks and the samples harvested and processed for histological and histomorphometrical analysis of soft tissue attachment to the implant surface. Significant higher soft tissue attachment was observed in the MAO-modified group compared to the control. The in vivo data indicated that MAO-modified Ti alloy could be a useful biomaterial for tissue engineering and benefit applications where bone-anchored transcutaneous implants are used.
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页数:7
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