Heparin sensing and binding - taking supramolecular chemistry towards clinical applications

被引：169

作者：

Bromfield, Stephen M. ^{[1
]}

Wilde, Ellis ^{[1
]}

Smith, David K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMICAL SOCIETY REVIEWS | 2013年 / 42卷 / 23期

基金：

英国生物技术与生命科学研究理事会;

关键词：

MOLECULAR-WEIGHT HEPARIN; HIGH-AFFINITY; CARDIAC-SURGERY; IN-VITRO; CONJUGATED POLYELECTROLYTES; ELECTROCHEMICAL SENSOR; UNFRACTIONATED HEPARIN; COLORIMETRIC SENSOR; SELECTIVE PROBE; PROTAMINE LMWP;

D O I：

10.1039/c3cs60278h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heparin is a vital biomolecule in widespread clinical use as an anti-coagulant. Heparin sensors have potential applications in the bedside detection of heparin levels in human blood during surgery, while high-affinity heparin binders may enable the development of effective heparin reversal agents for use in patients once surgery is complete. However, human blood is a challenging medium in which to achieve selective high-affinity molecular recognition, and as such, this system provides a fascinating challenge to supramolecular chemists. This has encouraged research using a variety of different systems and is stimulating new approaches to the application of molecular recognition. This review article provides an overview of research from both clinical and supramolecular communities towards heparin binding and sensing and considers how this area may develop in the future.

引用

页码：9184 / 9195

页数：12

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