Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans

被引:276
作者
Hull, CM
Johnson, AD [1 ]
机构
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
关键词
D O I
10.1126/science.285.5431.1271
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha 1, and alpha 2 of the Saccharomyces cerevisiae mating-type (MAT) Locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like Locus that is similar to the mating-type Loci of other fungi. In addition to the transcriptional regulators a1, alpha 1, and alpha 2, the C. albicans mating type-like Locus contains several genes not seen in other fungal MAT Loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.
引用
收藏
页码:1271 / 1275
页数:5
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