Blood-Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

被引：64

作者：

Wu, Yingxi ^{[1
,2
]}

Wu, Haijian ^{[1
,2
,3
]}

Guo, Xinying ^{[1
,2
]}

Pluimer, Brock ^{[1
,2
,4
]}

Zhao, Zhen ^{[1
,2
,4
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Ctr Neurodegenerat & Regenerat, Zilkha Neurogenet Inst, Los Angeles, CA 90007 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Physiol & Neurosci, Los Angeles, CA 90007 USA

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou, Peoples R China

[4] Univ Southern Calif, Keck Sch Med, Neurosci Grad Program, Los Angeles, CA 90007 USA

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

基金：

美国国家卫生研究院;

关键词：

mild traumatic brain injury; blood-brain barrier; murine model; vascular link; neurodegenerative diseases; MICROVASCULAR INJURY; MOUSE MODEL; HEAD-INJURY; CONCUSSION; DISRUPTION; DEFICITS; DISEASE;

D O I：

10.3389/fphys.2020.01030

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a robust environmental risk factor for neurodegenerative diseases including Alzheimer's disease (AD). Besides direct neuronal injury and neuroinflammation, blood-brain barrier (BBB) dysfunction is also a hallmark event of the pathological cascades after mTBI. However, the vascular link between BBB impairment caused by mTBI and subsequent neurodegeneration remains undefined. In this review, we focus on the preclinical evidence from murine models of BBB dysfunction in mTBI and provide potential mechanistic links between BBB disruption and the development of neurodegenerative diseases.

引用

页数：11

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