SOX6: a double-edged sword for Ewing sarcoma

被引：4

作者：

Marchetto, Aruna ^{[1
]}

Gruenewald, Thomas G. P. ^{[1
,2
,3
,4
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Inst Pathol, Fac Med, Max Eder Res Grp Pediat Sarcoma Biol, Munich, Germany

[2] German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Div Translat Pediat Sarcoma Res, Heidelberg, Germany

[3] Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany

[4] Heidelberg Univ Hosp, Inst Pathol, Heidelberg, Germany

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2020年 / 7卷 / 05期

关键词：

SOX6; Ewing sarcoma; Elesclomol; EWSR1-FLI1; vulnerability; biomarker; oxidative-stress; APOPTOSIS;

D O I：

10.1080/23723556.2020.1783081

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Developmental pathways play an important role in cancer. We have recently demonstrated that the constitutive activation of the developmental transcription factor SOX6 via the fusion oncoproteinne EWSR1-FLI1 (Ewing sarcoma breakpoint region 1 - Friend leukemia virus integration 1) contributes to the aggressive phenotype of Ewing sarcoma but on another hand provides an opportunity for targeted therapy.

引用

页数：3

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