Synthesis of a New Series of N-Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases

被引：10

作者：

Afsah, Elsayed M. ^{[1
]}

Fadda, Ahmad A. ^{[1
]}

Hanash, Ahlam H. ^{[1
]}

机构：

[1] Mansoura Univ, Dept Chem, Fac Sci, ET-35516 Mansoura, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 03期

关键词：

SOLID ACID SO42-/TIO2; POTENTIAL ANTICONVULSANTS; DERIVATIVES; ANTIBACTERIAL; HYDRAZONES; CHEMISTRY;

D O I：

10.1002/jhet.3097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of isatin 1 with benzaldehyde and a sec-amine or the appropriate aldimine afforded the N-Mannich bases 2-3 and the bis-base 4. Treatment of 1 with glutaric dialdehyde and morpholine gave the bis-base 5. Mannich reaction of the Schiff bases 6a-f derived from 1, led to the new Mannich bases and bis-bases 7-9. The use of N-methyl-D-glucamine as the amine component in the Mannich reaction with 6b-f led to the polyhydroxy Mannich bases 11-13.

引用

页码：736 / 742

页数：7

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