The Hopkins Verbal Learning Test and screening for dementia

被引:89
作者
Hogervorst, E
Combrinck, M
Lapuerta, P
Rue, J
Swales, K
Budge, M
机构
[1] Univ Oxford, Oxford Project Invest Mem & Ageing, OPTIMA, Oxford OX2 6HE, England
[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NY USA
[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, New Brunswick, NJ 08903 USA
关键词
NINCDS/ADRDA; sensitivity; specificity; Hopkins Verbal Learning Test; Alzheimer's disease; dementia; verbal memory; MMSE; screening;
D O I
10.1159/000048628
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
present study investigated the sensitivity and specificity of the Hopkins Verbal Learning Test (HVLT) for demented patients (n = 82, using NINCDS criteria) and 114 healthy controls-equivalent in age, years of education and gender-ratio-from the Oxford Projectto Investigate Memory and Ageing. The HVLT 'Total Recall' score had 87% sensitivity and 98% specificity for dementia using a cut-off score of 14.5. Using a 'Memory' score (the sum of the 'Total Recall' and the 'Discrimination Index') with a cut-off score of 24.5 gave a 91% sensitivity and 98% specificity for Alzheimer's disease cases when compared to controls. Unlike the MMSE, the HVLT has no ceiling effects and does not have to be adjusted for education. We conclude that the HVLT is an easy to administer, quick and well tolerated tool for the screening of dementia. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码:13 / 20
页数:8
相关论文
共 23 条
[1]   NEUROPSYCHOLOGICAL DIFFERENTIATION OF ALZHEIMERS-DISEASE FROM VASCULAR DEMENTIA [J].
BARR, A ;
BENEDICT, R ;
TUNE, L ;
BRANDT, J .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 1992, 7 (09) :621-627
[2]   Hopkins Verbal Learning Test Revised: Normative data and analysis of inter-form and test-retest reliability [J].
Benedict, RHB ;
Schretlen, D ;
Groninger, L ;
Brandt, J .
CLINICAL NEUROPSYCHOLOGIST, 1998, 12 (01) :43-55
[3]  
Brandt J., 1991, CLIN NEUROPSYCHOL, V5, P125, DOI [10.1080/13854049108403297, DOI 10.1080/13854049108403297]
[4]   Plasma total homocysteine and cognitive performance in a volunteer elderly population [J].
Budge, M ;
Johnston, C ;
Hogervorst, E ;
De Jager, C ;
Milwain, E ;
Iversen, SD ;
Barnetson, L ;
King, E ;
Smith, AD .
VASCULAR FACTORS IN ALZHEIMER'S DISEASE, 2000, 903 :407-410
[5]  
*CAMDEX, 1988, CAMBR EX MENT DIS EL
[6]  
Carpenter B, 1995, J CLIN GEROPSYCHOL, V1, P107
[7]   Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease [J].
Clarke, R ;
Smith, AD ;
Jobst, KA ;
Refsum, H ;
Sutton, L ;
Ueland, PM .
ARCHIVES OF NEUROLOGY, 1998, 55 (11) :1449-1455
[8]   DIFFERENTIAL-DIAGNOSIS OF DEMENTIA - A PROSPECTIVE EVALUATION OF THE DAT INVENTORY [J].
COEN, RF ;
OMAHONEY, D ;
BRUCE, I ;
LAWLOR, BA ;
WALSH, JB ;
COAKLEY, D .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (01) :16-20
[9]  
Craik FI M., 1982, Aging and cognitive processes, P191, DOI [10.1007/978-1-4684-4178-9_11, DOI 10.1007/978-1-4684-4178-9_11]
[10]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198