PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment

被引：63

作者：

Liu, Xiaoyan ^{[1
]}

Xu, Yan ^{[1
]}

Zhou, Qing ^{[1
]}

Chen, Minjiang ^{[1
]}

Zhang, Yu ^{[1
]}

Liang, Hongge ^{[1
]}

Zhao, Jing ^{[1
]}

Zhong, Wei ^{[1
]}

Wang, Mengzhao ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Dept Pulm Med, Peking Union Med Coll Hosp, Peking Union Med Coll,Lung Canc Ctr, Beijing 100730, Peoples R China

来源：

FUTURE ONCOLOGY | 2018年 / 14卷 / 07期

关键词：

cancer; microenvironment; PI3K; ENDOTHELIAL GROWTH-FACTOR; COMPREHENSIVE GENOMIC CHARACTERIZATION; SIGNAL-TRANSDUCTION PATHWAY; SQUAMOUS-CELL CARCINOMAS; P85 REGULATORY SUBUNIT; PHOSPHOINOSITIDE; 3-KINASE; PHOSPHATIDYLINOSITOL; PIK3CA GENE; BREAST-CANCER; CLASS-I;

D O I：

10.2217/fon-2017-0588

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of PI3K in cancer has been well established, and mutations of PIK3CA, the gene coding for catalytic subunit p110a of PI3K, are found in approximately 30% human cancers. The hyperactivated PI3K pathway plays a central role in the tumor cell activities such as proliferation, differentiation, chemotaxis, survival, trafficking and metabolism. Besides, PI3K pathway is involved in the regulation of angiogenesis and the host immune response against cancer. Therefore, the inhibition of PI3K pathway can yield multifaceted tumor cell-extrinsic effects that may synergize with chemotherapy, and more importantly, with the newly revived immunotherapy. Here, we review the structures and activation modes of PI3Ks and its implications in angiogenesis, extracellular matrix remodeling and tumor immunity.

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页码：665 / 674

页数：10

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