Analysis of HLA-G protein expression in leprosy

被引：1

作者：

da Silva, Camila Rodrigues ^{[1
]}

Sampaio, Lucas Henrique Ferreira ^{[2
]}

Costa, Mauricio Barcelos ^{[1
]}

de Paula Carneiro Cysneiros, Maria Auxiliadora ^{[1
]}

Sadissou, Ibrahim Abiodoun ^{[3
]}

de Oliveira Rodrigues Castilho, Mirian Lane ^{[1
]}

de Moraes, Jonathan Ballico ^{[2
]}

Donadi, Eduardo Antonio ^{[3
]}

Wastoswki, Isabela Jube ^{[2
,4
]}

机构：

[1] Univ Fed Goias UFG, Goiania, Go, Brazil

[2] Univ Estadual Goias UEG, Goiania, Go, Brazil

[3] Univ Sao Paulo, Ribeirao Preto, SP, Brazil

[4] Mol Immunol Lab UEG UnU Laranjeiras, Ave Prof Alfredo de Castro S-N, BR-74855130 Goiania, Go, Brazil

来源：

IMMUNOGENETICS | 2020年 / 72卷 / 05期

关键词：

HLA; HLA-G; Leprosy; Immune response;

D O I：

10.1007/s00251-020-01168-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The aim of this study was to evaluate the expression of human leukocyte antigen G (HLA-G) in leprosy. Biopsy and serum samples were collected from 18 patients presenting with leprosy and from healthy controls. Samples were analyzed using immunohistochemistry and ELISA techniques. HLA-G expression was observed in biopsy samples of all patients. The healthy control samples were consistently negative for HLA-G expression. Control plasma samples displayed significantly higher HLA-G expression than those from the patients (p < 0.01). These results are the first demonstration of the expression of HLA-G in leprosy.

引用

页码：333 / 337

页数：5

共 10 条

[1] HLA-G haplotype structure shows good conservation between different populations and good correlation with high, normal and low soluble HLA-G expression
Di Cristofaro, Julie
El Moujally, Dima
Agnel, Anais
Mazieres, Stephane
Cortey, Marti
Basire, Agnes
Chiaroni, Jacques
Picard, Christophe
[J]. HUMAN IMMUNOLOGY, 2013, 74 (02) : 203 - 206
[2] The clinicopathologic significance of the expression of HLA-G in oral squamous cell carcinoma
Goncalves, Andreia Souza
Wastowski, Isabela Jube
Capeletti, Lucas Raineri
Sacono, Nancy Tomoko
Cortez, Alane Pereira
Valadares, Marize Campos
Silva, Tarcilia Aparecida
Batista, Aline Carvalho
[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2014, 117 (03): : 361 - 368
[3] T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible
Huang, Yu-Hwa
Zozulya, Alla L.
Weidenfeller, Christian
Schwab, Nicholas
Wiendl, Heinz
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (02) : 273 - 281
[4] The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy
Lucena-Silva, N.
Teixeira, M. A. G.
Ramos, A. de L.
de Albuquerque, R. S.
Diniz, G. T. N.
Mendes-Junior, C. T.
Castelli, E. C.
Donadi, E. A.
[J]. MOLECULAR GENETICS & GENOMIC MEDICINE, 2013, 1 (03): : 123 - 130
[5] Report of the Wet Workshop for Quantification of soluble HLA-G in Essen, 2004
Rebmann, V
LeMaoult, J
Rouas-Freiss, N
Carosella, ED
Grosse-Wilde, H
[J]. HUMAN IMMUNOLOGY, 2005, 66 (08) : 853 - 863
[6] Ridley D S, 1966, Int J Lepr Other Mycobact Dis, V34, P255
[7] Evaluation of various cytokines elicited during antigen-specific recall as potential risk indicators for the differential development of leprosy
Sampaio, L. H.
Sousa, A. L. M.
Barcelos, M. C.
Reed, S. G.
Stefani, M. M. A.
Duthie, M. S.
[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2012, 31 (07) : 1443 - 1451
[8] Genetics of leprosy: Expected and unexpected developments and perspectives
Sauer, Monica E. D.
Salomao, Heloisa
Ramos, Geovana B.
D'Espindula, Helena R. S.
Rodrigues, Rafael S. A.
Macedo, Wilian C.
Sindeaux, Renata H. M.
Mira, Marcelo T.
[J]. CLINICS IN DERMATOLOGY, 2015, 33 (01) : 99 - 107
[9] SIELING PA, 1994, J IMMUNOL, V153, P3639
[10] A short history of HLA
Thorsby, E.
[J]. TISSUE ANTIGENS, 2009, 74 (02): : 101 - 116

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