Dementia with Lewy bodies: an update and outlook

被引：246

作者：

Outeiro, Tiago Fleming ^{[1
,2
,3
]}

Koss, David J. ^{[1
]}

Erskine, Daniel ^{[1
]}

Walker, Lauren ^{[1
]}

Kurzawa-Akanbi, Marzena ^{[1
]}

Burn, David ^{[1
]}

Donaghy, Paul ^{[1
]}

Morris, Christopher ^{[1
]}

Taylor, John-Paul ^{[1
]}

Thomas, Alan ^{[1
]}

Attems, Johannes ^{[1
]}

McKeith, Ian ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Inst Neurosci, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Univ Med Ctr Gottingen, Ctr Biostruct Imaging Neurodegenerat, Ctr Nanoscale Microscopy & Mol Physiol Brain, Dept Expt Neurodegenerat, Gottingen, Germany

[3] Max Planck Inst Expt Med, Gottingen, Germany

来源：

MOLECULAR NEURODEGENERATION | 2019年 / 14卷 / 1期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Dementia with Lewy bodies; Alpha-synuclein; Dementia; Alzheimer's disease; Biomarkers; PHOSPHORYLATED ALPHA-SYNUCLEIN; PARKINSONS-DISEASE DEMENTIA; AUTOPSY-CONFIRMED DEMENTIA; MIXED BRAIN PATHOLOGIES; ALZHEIMERS-DISEASE; BODY-DISEASE; COGNITIVE IMPAIRMENT; CLINICAL-DIAGNOSIS; GLUCOCEREBROSIDASE MUTATIONS; MYOCARDIAL SCINTIGRAPHY;

D O I：

10.1186/s13024-019-0306-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated alpha-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson's disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.

引用

页数：18

共 212 条

[1]

American Psychiatric Association, 2013, DIAGNOSTIC STAT MANU

[2]

[Anonymous], INT J ALZHEIMERS DIS

[3] Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies [J].

Arai, Tetsuaki ;

Mackenzie, Ian R. A. ;

Hasegawa, Masato ;

Nonoka, Takashi ;

Niizato, Kazhuhiro ;

Tsuchiya, Kuniaki ;

Iritani, Shuji ;

Onaya, Mitsumoto ;

Akiyama, Haruhiko .

ACTA NEUROPATHOLOGICA, 2009, 117 (02) :125-136

[4] Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study [J].

Babiloni, Claudio ;

Del Percio, Claudio ;

Lizio, Roberta ;

Noce, Giuseppe ;

Lopez, Susanna ;

Soricelli, Andrea ;

Ferri, Raffaele ;

Nobili, Flavio ;

Arnaldi, Dario ;

Fama, Francesco ;

Aarsland, Dag ;

Orzi, Francesco ;

Buttinelli, Carla ;

Giubilei, Franco ;

Onofrj, Marco ;

Stocchi, Fabrizio ;

Stirpe, Paola ;

Fuhr, Peter ;

Gschwandtner, Ute ;

Ransmayr, Gerhard ;

Garn, Heinrich ;

Fraioli, Lucia ;

Pievani, Michela ;

Frisoni, Giovanni B. ;

D'Antonio, Fabrizia ;

De Lena, Carlo ;

Guntekin, Bahar ;

Hanoglu, Lutfu ;

Bazar, Erol ;

Yener, Gorsev ;

Emek-Savas, Derya Durusu ;

Triggiani, Antonio Ivano ;

Franciotti, Raffaella ;

Taylor, John Paul ;

Vacca, Laura ;

De Pandis, Maria Francesca ;

Bonanni, Laura .

NEUROBIOLOGY OF AGING, 2018, 65 :18-40

[5] Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study [J].

Babiloni, Claudio ;

Del Percio, Claudio ;

Lizio, Roberta ;

Noce, Giuseppe ;

Cordone, Susanna ;

Lopez, Susanna ;

Soricelli, Andrea ;

Ferri, Raffaele ;

Pascarelli, Maria Teresa ;

Nobili, Flavio ;

Arnaldi, Dario ;

Aarsland, Dag ;

Orzi, Francesco ;

Buttinelli, Carla ;

Giubilei, Franco ;

Onofrj, Marco ;

Stocchi, Fabrizio ;

Stirpe, Paola ;

Fuhr, Peter ;

Gschwandtner, Ute ;

Ransmayr, Gerhard ;

Caravias, Georg ;

Garn, Heinrich ;

Sorpresi, Fabiola ;

Pievani, Michela ;

Frisoni, Giovanni B. ;

D'Antonio, Fabrizia ;

De Lena, Carlo ;

Guntekin, Bahar ;

Hanoglu, Lutfu ;

Basar, Erol ;

Yener, Gorsev ;

Emek-Savas, Derya Durusu ;

Triggiani, Antonio Ivano ;

Franciotti, Raffaella ;

De Pandis, Maria Francesca ;

Bonanni, Laura .

NEUROBIOLOGY OF AGING, 2017, 55 :143-158

[6] Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with Lewy bodies [J].

Ballard, CG ;

Jacoby, R ;

Del Ser, T ;

Khan, MN ;

Munoz, DG ;

Holmes, C ;

Nagy, Z ;

Perry, EK ;

Joachim, C ;

Jaros, E ;

O'Brien, JT ;

Perry, RH ;

McKeith, IG .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (05) :843-849

[7] Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders [J].

Beach, Thomas G. ;

Adler, Charles H. ;

Serrano, Geidy ;

Sue, Lucia I. ;

Walker, D. G. ;

Dugger, Brittany N. ;

Shill, Holly A. ;

Driver-Dunckley, Erika ;

Caviness, John N. ;

Intorcia, Anthony ;

Filon, Jessica ;

Scott, Sarah ;

Garcia, Angelica ;

Hoffman, Brittany ;

Belden, Christine M. ;

Davis, Kathryn J. ;

Sabbagh, Marwan N. .

JOURNAL OF PARKINSONS DISEASE, 2016, 6 (01) :153-163

[8] Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders [J].

Beach, Thomas G. ;

Adler, Charles H. ;

Sue, Lucia I. ;

Vedders, Linda ;

Lue, LihFen ;

White, Charles L., III ;

Akiyama, Haru ;

Caviness, John N. ;

Shill, Holly A. ;

Sabbagh, Marwan N. ;

Walker, Douglas G. .

ACTA NEUROPATHOLOGICA, 2010, 119 (06) :689-702

[9]

Beach TG, 2009, ACTA NEUROPATHOL, V117, P169, DOI 10.1007/s00401-008-0450-7

[10]

Benamer HTS, 2000, MOVEMENT DISORD, V15, P503, DOI 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →