The Urokinase Receptor in Hematopoietic Stem Cells Mobilization

被引：3
作者：
Blasi, Francesco [1 ,2 ]
机构：
[1] Ist Sci San Raffaele, I-20132 Milan, Italy
[2] IFOM FIRC Inst Mol Oncol, I-20136 Milan, Italy
来源：
CURRENT PHARMACEUTICAL DESIGN | 2011年 / 17卷 / 19期
关键词：
Urokinase receptor; hematopoietic stem cells; mobilization; plasminogen activation; PLASMINOGEN-ACTIVATOR RECEPTOR; IN-VIVO; OBSTRUCTIVE NEPHROPATHY; HUMAN CARCINOMA; LINKER REGION; MIGRATION; UPAR; VITRONECTIN; COMPLEX; RECRUITMENT;
D O I：
10.2174/138161211796718206
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The receptor for urokinase plasminogen activator (uPAR) is required in hematopoietic stem/progenitor cells (HSC, HPC) mobilization in the mouse. Indeed, uPAR Ko mice are deficient both in retention and mobilization of HSC and HPC, because uPAR causes their retention in the BM through its interaction with the 4 1 integrin and at the same time its removal promotes their migration. Normally, the membrane signal is cleaved by plasmin which on one side releases the cells from their osteoblasts interaction and on the other produces a cleaved soluble uPAR product that stimulates mobilization. Available data suggest that a similar mechanism may take place in humans.
引用
收藏
页码：1911 / 1913
页数：3
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