New Naphthalene-Chroman Coupling Products from the Endophytic Fungus, Nodulisporium sp from Erica arborea

Six novel metabolites, nodulisporins D-F (1-3), (3S,4S,5R)-2,4,6-trimethyloct-6-ene-3,5-diol (4), 5-hydroxy-2-hydroxymethyl-4H-chromen-4-one (5) and 3-(2,3-dihydroxyphenoxy)-butanoic acid (6) were isolated together with seven known compounds (7-13) from the culture extract of the endophytic fungus Nodulisporium sp. The relative configurations of these new compounds were determined by means of spectroscopic data, including HREIMS, H-1 NMR, C-13 NMR and 2D NMR (HMQC, HMBC and NOESY). The novel compounds exhibit antifungal and antialgal activities and most of them were also antibacterial. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim Germany, 2009)