Neoadjuvant Treatment Options in Soft Tissue Sarcomas

被引：27
作者：
Spalek, Mateusz Jacek [1 ]
Kozak, Katarzyna [1 ]
Czarnecka, Anna Malgorzata [1 ,2 ]
Bartnik, Ewa [3 ,4 ]
Borkowska, Aneta [1 ]
Rutkowski, Piotr [1 ]
机构：
[1] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Soft Tissue Bone Sarcoma & Melanoma, PL-02781 Warsaw, Poland
[2] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Expt Pharmacol, PL-02106 Warsaw, Poland
[3] Univ Warsaw, Fac Biol, Inst Genet & Biotechnol, PL-02106 Warsaw, Poland
[4] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
来源：
CANCERS | 2020年 / 12卷 / 08期
关键词：
soft tissue sarcoma; neoadjuvant treatment; combined treatment; RANDOMIZED CLINICAL-TRIAL; PHASE-I TRIAL; INDUCED PATHOLOGICAL NECROSIS; ADJUVANT RADIATION-THERAPY; RECURRENT BREAST-CANCER; HIGH-RISK EXTREMITY; POSTOPERATIVE RADIOTHERAPY; PREOPERATIVE RADIOTHERAPY; HIGH-GRADE; HYPOFRACTIONATED RADIOTHERAPY;
D O I：
10.3390/cancers12082061
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Due to the heterogeneity of soft tissue sarcomas (STS), the choice of the proper perioperative treatment regimen is challenging. Neoadjuvant therapy has attracted increasing attention due to several advantages, particularly in patients with locally advanced disease. The number of available neoadjuvant modalities is growing continuously. We may consider radiotherapy, chemotherapy, targeted therapy, radiosensitizers, hyperthermia, and their combinations. This review discusses possible neoadjuvant treatment options in STS with an emphasis on available evidence, indications for each treatment type, and related risks. Finally, we summarize current recommendations of the STS neoadjuvant therapy response assessment.
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页码：1 / 23
页数：23
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