Topiramate in patients with epilepsy and intellectual disability

被引：14

作者：

Martin, Peter ^{[1
]}

Schreiner, Andreas ^{[2
]}

Rettig, Klaus ^{[3
]}

Schaeuble, Barbara ^{[2
]}

机构：

[1] Epilepsy Ctr Kork, Seguin Clin Persons Severe Intellectual Disabil, Kehl, Germany

[2] Janssen Cilag GmbH, Neuss, Germany

[3] Gesell Evaluat & Qualitatssicherung Med, GEM, Meerbusch, Germany

来源：

EPILEPSY & BEHAVIOR | 2009年 / 14卷 / 03期

关键词：

Topiramate; Epilepsy; Intellectual disability; Seizure; Behavior; Aberrant Behavior Checklist (ABC); Matson Evaluation of Social Skills for Individuals with Severe Retardation (MESSIER) scale; SEVERE RETARDATION MESSIER; LENNOX-GASTAUT-SYNDROME; MATSON EVALUATION; SOCIAL-SKILLS; CONTROLLED-TRIAL; ADVERSE EVENTS; WEST-SYNDROME; INDIVIDUALS; CHILDREN; ADULTS;

D O I：

10.1016/j.yebeh.2008.12.017

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This noninterventional single-arm study explored effectiveness and behavioral outcomes in intellectually disabled patients treated with topiramate for epilepsy. Data from 21 patients diagnosed with cerebral palsy were available for evaluation. Behavioral changes were assessed using the validated Aberrant Behavior Checklist and Matson Evaluation of Social Skills for individuals with Severe Retardation (MESSIER) scales. Some improvement in nearly all behavioral aspects was observed under concomitant topiramate therapy; for example, the Aberrant Behavior Checklist total score changed from 33.7 +/- 25.8 to 25.3 +/- 19.1 (P = 0.047). In addition, seizure frequency decreased from 16.1 +/- 22.2/4 weeks to 12.2 +/- 17.0/4 weeks (N = 2 1, P = 0.164). Fifty-two percent of the patients experienced at least 50% seizure reduction during the 24-week treatment period. The safety profile is in accordance with the current Summary of Product Characteristics of Topiramate. Two unexpected deaths were attributed to sudden unexpected death in epilepsy. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：496 / 502

页数：7

共 26 条

[11] Topiramate in children with west syndrome: A retrospective multicenter evaluation of 100 patients [J].

Korinthenberg, Rudolf ;

Schreiner, Andreas .

JOURNAL OF CHILD NEUROLOGY, 2007, 22 (03) :302-306

[12] Conversion from carbamazepine or oxcarbazepine to topiramate in adolescents and adults with epilepsy [J].

Kowalik, A. ;

Rimpau, W. ;

Adam, H. ;

Kuehn, F. ;

van Oene, J. ;

Schreiner, A. ;

Bogdanow, M. ;

Schauble, B. .

ACTA NEUROLOGICA SCANDINAVICA, 2008, 117 (03) :159-166

[13] Early identification of refractory epilepsy. [J].

Kwan, P ;

Brodie, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (05) :314-319

[14] Clinical pharmacology: Drugs as a benefit and/or risk in sudden unexpected death in epilepsy? [J].

Lathers, CM ;

Schraeder, PL .

JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 42 (02) :123-136

[15] Reliability of the Matson evaluation of social skills in individuals with severe retardation (MESSIER) [J].

Matson, JL ;

LeBlanc, LA ;

Weinheimer, B .

BEHAVIOR MODIFICATION, 1999, 23 (04) :647-661

[16] The convergent validity of the matson evaluation of social skills for individuals with severe retardation (MESSIER) [J].

Matson, JL ;

Carlisle, CB ;

Bamburg, JW .

RESEARCH IN DEVELOPMENTAL DISABILITIES, 1998, 19 (06) :493-500

[17] Cutoff Scores for the Matson Evaluation of Social Skills for Individuals With Severe Retardation (MESSIER) for Adults With Intellectual Disability [J].

Matson, Johnny L. ;

Boisjoli, Jessica A. .

BEHAVIOR MODIFICATION, 2008, 32 (01) :109-120

[18]

Mula M, 2007, EPILEPSIA, V48, P2322

[19] Factor structure of the Matson Evaluation of Social Skills for Individuals with Severe Retardation (MESSIER) [J].

Paclawskyj, TR ;

Rush, KS ;

Matson, JL ;

Cherry, KE .

BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 1999, 38 :289-293

[20]

Pellock JM, 2000, MENT RETARD DEV D R, V6, P309, DOI 10.1002/1098-2779(2000)6:4<309::AID-MRDD10>3.0.CO

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