Polarographic determination of diazepam with its parallel catalytic wave in the presence of persulfate

被引：28

作者：

Guo, W ^{[1
]}

Lin, H

Liu, LM

Song, JF

机构：

[1] NW Univ Xian, Dept Chem, Xian 710069, Peoples R China

[2] Yuxi Teachers Coll, Dept Chem, Yuxi 653100, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

diazepam; persulfate; polarographic catalytic wave;

D O I：

10.1016/j.jpba.2003.12.006

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new method for the determination of diazepam was proposed based on its polarographic catalytic wave in the presence of persulfate. In 0.20 M NaAc-HAc (pH 4.7)-2.0 x 10(-2) M K2S2O8 supporting electrolyte, the reduction wave of diazepam with peak potential -0.89 V (versus SCE) was catalyzed, producing a parallel catalytic wave. The peak current of the catalytic wave was 15 times higher than that of the corresponding reduction wave for 4.0 x 10(-6) M diazepam, and was rectilinear to diazepam concentration in the range of 5.6 x 10(-8) to 8.8 x 10(-6) and 8.8 x 10(-6) to 2.0 x 10(-4) M. The detection limit was 9.6 x 10(-9) M. The mechanism of the parallel catalytic wave of diazepam was discussed. (C) 2003 Elsevier B.V All rights reserved.

引用

页码：1137 / 1144

页数：8

共 30 条

[1] High-performance liquid chromatographic determination of amfepramone hydrochloride, mazindol, and diazepam in tablets [J].