Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells

被引:26
作者
Zimmer, Michael I. [1 ,3 ]
Nguyen, Hanh P. [1 ]
Wang, Bin [1 ]
Xu, Honglin [1 ]
Colmone, Angela [1 ]
Felio, Kyrie [1 ,3 ]
Choi, Hak-Jong [1 ,3 ]
Zhou, Ping [2 ]
Alegre, Maria-Luisa [2 ]
Wang, Chyung-Ru [1 ,3 ]
机构
[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA
[3] Northwestern Univ, Dept Microbiol & Immunol, Chicago, IL 60611 USA
基金
美国国家卫生研究院;
关键词
T cell activation; T cell development; NKT CELLS; CLASS-I; ALPHA-GALACTOSYLCERAMIDE; CRYSTAL-STRUCTURE; MOUSE CD1; MHC; RECOGNITION; GENES; MICE; MOLECULES;
D O I
10.1073/pnas.0808476106
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (V alpha 14i) and type II (non-V alpha 14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells. IMMUNOLOGY
引用
收藏
页码:1909 / 1914
页数:6
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