New polyhydroxylated steroid from the South China Sea gorgonian Anthogorgia caerulea

被引：10

作者：

Sun, Ling-Ling ^{[1
]}

Shao, Chang-Lun ^{[1
]}

Hang, Hui ^{[2
]}

Guo, Zhi-Yong ^{[3
]}

Xing, Qian ^{[1
]}

Wang, Chang-Yun ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharmaceut, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou 510000, Guangdong, Peoples R China

[3] China Three Gorges Univ, Coll Chem & Life Sci, Yichang 443002, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Anthogorgia caerulea; gorgonian coral; polyhydroxylated steroids; absolute configuration; POLYOXYGENATED STEROIDS; BRINE SHRIMP; MENELLA SP; CONSTITUENTS; ASSAY;

D O I：

10.1080/14786419.2012.717287

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new polyhydroxylated steroid, caerulsteroid A (1), along with nine known analogues (2-10), was isolated from the gorgonian coral Anthogorgia caerulea collected from the South China Sea. The structure of the new compound was elucidated by 1-D and 2-D NMR, and mass spectrometry. The absolute configuration of 1 was assigned on the basis of the absolute configurations of the related congeners 2 and 3, which were determined by application of the modified Mosher's method. The isolated compounds were assayed for their cytotoxicity, antimicrobial activity and lethality towards brine shrimp Artemia salina.

引用

页码：1159 / 1166

页数：8

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