Adhesion of Lactobacillus iners AB-1 to Human Fibronectin: A Key Mediator for Persistence in the Vagina?

被引：51

作者：

McMillan, Amy ^{[1
,2
,3
]}

Macklaim, Jean M. ^{[1
,4
]}

Burton, Jeremy P. ^{[2
,3
]}

Reid, Gregor ^{[1
,2
,3
]}

机构：

[1] St Josephs Hlth Care, Lawson Hlth Res Inst, Canadian Res & Dev Ctr Probiot, London, ON, Canada

[2] Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada

[3] Univ Western Ontario, Dept Surg, London, ON N6A 3K7, Canada

[4] Univ Western Ontario, Dept Biochem, London, ON, Canada

来源：

REPRODUCTIVE SCIENCES | 2013年 / 20卷 / 07期

关键词：

Lactobacillus iners; fibronectin; bacterial vaginosis; PLACEBO-CONTROLLED TRIAL; BACTERIAL VAGINOSIS; FUSION INHIBITORS; BINDING PROTEIN; JAPANESE WOMEN; RHAMNOSUS GR-1; HEALTHY WOMEN; URINARY-TRACT; REUTERI RC-14;

D O I：

10.1177/1933719112466306

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Lactobacillus iners is prominent in the human vagina and is able to persist despite development of bacterial vaginosis and treatment with antibiotics. A probable factor in its persistent survival is its ability to be retained in the vaginal epithelia. Genome sequencing of the strain showed an organism deplete of many metabolic pathways, yet equipped with fibronectin (Fn)-binding adhesins. The objective of the present study was to assess the ability of L iners AB-1 to bind immobilized Fn. Results showed that the organism superiorly bound the protein compared to other species of Lactobacillus and known binders such as Staphylococcus aureus. Treatment of L iners cells by protease rendered its binding abilities to Fn nonfunctional. The findings indicate a mechanism of vaginal persistence for a Lactobacillus species, with implications for reproductive health.

引用

页码：791 / 796

页数：6

共 31 条

[1] The complex fibronectin-Trichomonas vaginalis interactions and Trichomonosis [J].