Natural specimens in museum collections can play a very important role in South Africa's school curriculum, which emphasises that Indigenous Knowledge should be considered during the teaching and learning processes. However, the Department of Basic Education has been criticised for lack of learning and teaching ways that are more user-friendly and relevant to learners' everyday lives, particularly in terms of ethnobotany as a branch of Indigenous Knowledge. Similarly, educators who have visited the Selmar Schonland Herbarium of the Albany Museum in Grahamstown, Eastern Cape confirm this need. This study uses ethnobotany which is the scientific study of the traditional knowledge and customs of people concerning wild plants and their food, medical, medicinal, religious, and other uses. The role of ethnobotany is explored by the museum herbarium in integrating Indigenous Knowledge during teaching and learning in the discipline of science education, by making use of wild edible plants. The role of Indigenous Knowledge to enhance the conceptual understanding of science education is important, as there is little which has been translated into curriculum perspectives and learning support. To fulfil the requirements and demands of the current school curriculum, there is a need to reconsider and redress the errors made by the previous system of education in South Africa. Findings of the study demonstrated the effectiveness of a hands-on practical, museum-specific education approach to introduce learners to the herbarium, ethnobotany, and the important role of Indigenous Knowledge.