Synthesis of acridine cyclic imide hybrid molecules and their evaluation for anticancer activity

被引：17

作者：

Kumar, Anuj ^{[1
]}

Kumar, Nikhil ^{[2
]}

Roy, Partha ^{[2
]}

Sondhi, S. M. ^{[1
]}

Sharma, Anuj ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 08期

关键词：

Microwave-assisted synthesis; Acridine cyclic imide; Human cancer cell lines; Anticancer; POTENT ANTITUMOR 9-ANILINOACRIDINES; N-MUSTARD RESIDUE; BIOLOGICAL EVALUATION; RADIONUCLIDE THERAPY; DERIVATIVES; BEARING; DESIGN; ANTIBACTERIAL; AGENTS;

D O I：

10.1007/s00044-015-1380-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

9-Amino acridine derivatives (1a-e) on condensation with dihydrofuran-2,5-dione, hexahydroisobenzofuran-1,3-dione and isochroman-1,3-dione under microwave irradiation gave corresponding condensation products 2a-e, 3a-e and 4a-e, respectively, in good yields. All these compounds were screened in vitro for anticancer activity against five human cancer cell lines, i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1) and liver (Hep G2). Compounds 1-(3-methoxyacridine-9-yl) pyrrolidine-2,5-dione (2d) (ovary PA-1), 2-(2-methylacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3b) (lung NCl H-522), 2-(4-methylacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3c) (ovary PA-1), 2-(4-methoxyacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3e) (ovary PA-1) and 2-(2-methylacridine-9-yl)isoquinoline-1,3(2H,4H)-dione (4b) (ovary PA-1) exhibited IC50 values 7.1, 8.0, 5.4, 10.0 and 6.56 A mu M, respectively, and hence possess good anticancer activity.

引用

页码：3272 / 3282

页数：11

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