The effect of fecal microbiota transplantation on stroke outcomes: A systematic review

被引:6
|
作者
Pasokh, Amir [1 ]
Farzipour, Mohammad [1 ]
Mahmoudi, Javad [1 ]
Sadigh-Eteghad, Saeed [1 ]
机构
[1] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran
来源
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2022年 / 31卷 / 11期
关键词
Fecal microbiota transplantation; Stroke; Ischemia; Gut-brain axis; ISCHEMIC-STROKE; GUT MICROBIOTA; ENTERIC MICROBIOTA; BRAIN-INJURY; DYSBIOSIS;
D O I
10.1016/j.jstrokecerebrovasdis.2022.106727
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background and Purpose: Fecal microbiota transplantation (FMT) is a novel micro -biota-based therapeutic method that transfers stool from donor into a recipient and its application is under investigating for neurological disorders such as stroke. In this systematic review, we assessed the effect of FMT in progression and treatment of stroke and recovery of post-stroke complications. Methods: Preliminary studies were searched in MEDLINE via PubMed, Scopus, COCHRANE library and Google Scholar, databases up to February 2022. The search strategy was restricted to articles about FMT in stroke. The initial search yielded 4570 articles, of which 19 publications were included in our systematic review. Results: Based on outcomes transferring microbiome from healthy or ischemic donor to other ischemic recipient can affect brain infarct volume and survival rate, neurological and behavioral out-comes, and inflammatory pathways. Conclusions: Our systematic review on preclin-ical studies showed that manipulating gut microbiota via FMT can be a possible therapeutic approach for treatment of stroke and recovery of post-stroke complications.
引用
收藏
页数:11
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