Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels

被引：599

作者：

Li, Hui ^{[1
]}

Peng, Zhiyu ^{[2
]}

Yang, Xiaohong ^{[1
]}

Wang, Weidong ^{[1
]}

Fu, Junjie ^{[3
]}

Wang, Jianhua ^{[1
]}

Han, Yingjia ^{[1
]}

Chai, Yuchao ^{[1
]}

Guo, Tingting ^{[1
]}

Yang, Ning ^{[4
]}

Liu, Jie ^{[4
]}

Warburton, Marilyn L. ^{[5
]}

Cheng, Yanbing ^{[2
]}

Hao, Xiaomin ^{[1
]}

Zhang, Pan ^{[1
]}

Zhao, Jinyang ^{[2
]}

Liu, Yunjun ^{[3
]}

Wang, Guoying ^{[3
]}

Li, Jiansheng ^{[1
]}

Yan, Jianbing ^{[4
]}

机构：

[1] China Agr Univ, Natl Maize Improvement Ctr China, Beijing Key Lab Crop Genet Improvement, Beijing 100094, Peoples R China

[2] Beijing Genom Inst Shenzhen, Shenzhen, Peoples R China

[3] Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100193, Peoples R China

[4] Huazhong Agr Univ, Natl Key Lab Crop Genet Improvement, Wuhan, Peoples R China

[5] ARS, Corn Host Plant Resistance Res Unit, USDA, Starkville, MS USA

来源：

NATURE GENETICS | 2013年 / 45卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ACYL-CARRIER PROTEIN; FATTY-ACID; BRASSICA-NAPUS; GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE; QUANTITATIVE RESISTANCE; LEAF-BLIGHT; MIXED-MODEL; SELECTION; ENCODES; FAD2;

D O I：

10.1038/ng.2484

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Maize kernel oil is a valuable source of nutrition. Here we extensively examine the genetic architecture of maize oil biosynthesis in a genome-wide association study using 1.03 million SNPs characterized in 368 maize inbred lines, including 'high-oil' lines. We identified 74 loci significantly associated with kernel oil concentration and fatty acid composition (P < 1.8 x 10(-6)), which we subsequently examined using expression quantitative trait loci (QTL) mapping, linkage mapping and coexpression analysis. More than half of the identified loci localized in mapped QTL intervals, and one-third of the candidate genes were annotated as enzymes in the oil metabolic pathway. The 26 loci associated with oil concentration could explain up to 83% of the phenotypic variation using a simple additive model. Our results provide insights into the genetic basis of oil biosynthesis in maize kernels and may facilitate marker-based breeding for oil quantity and quality.

引用

页码：43 / U72

页数：10

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