Inventing new medicines: The FGF21 story

被引：171

作者：

Kharitonenkov, Alexei ^{[1
]}

Adams, Andrew C. ^{[1
]}

机构：

[1] Eli Lilly & Co, Diabet Res, Indianapolis, IN 46285 USA

来源：

MOLECULAR METABOLISM | 2014年 / 3卷 / 03期

关键词：

FGF21; LY2405319; Metabolism; Drug discovery; GROWTH-FACTOR; 21; INDUCED OBESE MICE; BETA-KLOTHO; ANTIDIABETIC ACTIONS; INSULIN SENSITIVITY; ENERGY-EXPENDITURE; PPAR-ALPHA; EXPRESSION; GLUCAGON; FIBROBLAST-GROWTH-FACTOR-21;

D O I：

10.1016/j.molmet.2013.12.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the discovery of insulin in 1921, protein therapeutics have become vital tools in the treatment of diabetes mellitus. This heritage has been extended with the comparatively recent introduction of recombinant and re-engineered insulins, in addition to the advent of GLP1 agonists. FGF21 represents an example of a novel experimental protein therapy which is able to induce favorable metabolic effects in various species ranging from rodents to man. The aim of this review is to communicate the story of the FGF21 drug discovery path from identification in a functional in vitro screen, to the eventual evaluation of its utility in patients. Given that the development of FGF21 advanced hand-in-hand with rapidly evolving scientific research around this target, we have also attempted to describe our view of recent developments regarding the mechanistic understanding of FGF21 biology. (C) 2013 The Authors. Published by Elsevier GmbH. Open access under CC BY-NC-ND license

引用

页码：221 / 229

页数：9

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