The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats

被引:155
作者
Davidson, Terry L. [1 ]
Monnot, Andrew [1 ]
Neal, Adelai U. [1 ]
Martin, Ashley A. [1 ]
Horton, J. Josiah [1 ]
Zheng, Wei [1 ]
机构
[1] Purdue Univ, Dept Psychol Sci, W Lafayette, IN 47907 USA
关键词
Hippocampus; High-fat diet; Obesity; Learning; Adiposity; Energy balance; Cognition; BODY-WEIGHT REGULATION; CONTEXTUAL RETRIEVAL; COGNITIVE FUNCTION; PREFRONTAL CORTEX; FOOD-INTAKE; HIGH-FAT; MEMORY; LESIONS; LEPTIN; INFLAMMATION;
D O I
10.1016/j.physbeh.2012.05.015
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Rats that consume high-energy (HE) diets (i.e., diets high in saturated fats and sugar) show impaired hippocampal-dependent learning and memory (e.g., Kanoski and Davidson (2011) [1]). To further investigate this effect, we trained rats given restricted access to low-fat lab chow on hippocampal-dependent serial feature-negative (FN) and hippocampal-independent simple discrimination problems. When training was completed, Group Chow received ad libitum lab chow. The remaining rats received ad libitum HE diet. Performance on both discrimination problems was tested following 7, 14, 21 and 28 days of HE diet exposure. FN, but not simple discrimination, was abolished initially for all rats, and then re-emerged for Group Chow. For rats fed HE diet, those that weighed the least and had the lowest amount of body fat (HE-diet resistant (HE-DR) rats), performed like Group Chow on both discrimination problems. However, HE diet-induced obese (HE-DIO) rats (i.e., rats that weighed the most weight and had the most body fat) performed like Group Chow on the simple discrimination problem, but were impaired throughout testing on the FN problem. Subsequent assessment of blood-brain barrier (BBB) permeability revealed that concentrations of an exo-genously administered dye were elevated in the hippocampus, but not in the striatum or prefrontal cortex for HE-DIO rats relative to the HE-DR and Chow groups. The results indicate that the adverse consequences of HE diet on hippocampal-dependent cognitive functioning are associated with detrimental effects on the BBB and that both of these outcomes vary with sensitivity to HE diet-induced increases in weight and adiposity. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:26 / 33
页数:8
相关论文
共 50 条
[1]   Impaired transport of leptin across the blood-brain barrier in obesity [J].
Banks, WA ;
DiPalma, CR ;
Farrell, CL .
PEPTIDES, 1999, 20 (11) :1341-1345
[2]  
Benoit SC, 1999, PSYCHOBIOLOGY, V27, P26
[3]   Memory processes in classical conditioning [J].
Bouton, ME ;
Moody, EW .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2004, 28 (07) :663-674
[4]   Obesity and vulnerability of the CNS [J].
Bruce-Keller, Annadora J. ;
Keller, Jeffrey N. ;
Morrison, Christopher D. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2009, 1792 (05) :395-400
[5]   Copper transport to the brain by the blood-brain barrier and blood-CSF barrier [J].
Choi, Byuny-Sun ;
Zheng, Wei .
BRAIN RESEARCH, 2009, 1248 :14-21
[6]   Insulin resistance and pathological brain ageing [J].
Cholerton, B. ;
Baker, L. D. ;
Craft, S. .
DIABETIC MEDICINE, 2011, 28 (12) :1463-1475
[7]   Little and often: Ingestive behavior patterns following hippocampal lesions in rats [J].
Clifton, PG ;
Vickers, SP ;
Somerville, EM .
BEHAVIORAL NEUROSCIENCE, 1998, 112 (03) :502-511
[8]   The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia Two Roads Converged [J].
Craft, Suzanne .
ARCHIVES OF NEUROLOGY, 2009, 66 (03) :300-305
[9]   Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology [J].
Cuello, A. C. ;
Ferretti, M. T. ;
Leon, W. C. ;
Iulita, M. F. ;
Melis, T. ;
Ducatenzeiler, A. ;
Bruno, M. A. ;
Canneva, F. .
NEURODEGENERATIVE DISEASES, 2010, 7 (1-3) :96-98
[10]   A potential role for the hippocampus in energy intake and body weight regulation [J].
Davidson, Terry L. ;
Kanoski, Scott E. ;
Schier, Lindsey A. ;
Clegg, Deborah J. ;
Benoit, Stephen C. .
CURRENT OPINION IN PHARMACOLOGY, 2007, 7 (06) :613-616