Metabolic Reprogramming in Tumor Endothelial Cells

被引：40

作者：

Garcia-Caballero, Melissa ^{[1
,2
,5
]}

Sokol, Liliana ^{[1
,2
]}

Cuypers, Anne ^{[1
,2
]}

Carmeliet, Peter ^{[1
,2
,3
,4
]}

机构：

[1] VIB, Ctr Canc Biol, Lab Angiogenesis & Vasc Metab, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Oncol, Lab Angiogenesis & Vasc Metab, B-3000 Leuven, Belgium

[3] Univ Aarhus, Dept Biomed, Lab Angiogenesis & Vasc Heterogene, DK-8000 Aarhus, Denmark

[4] Khalifa Univ Sci & Technol, Ctr Biotechnol, Abu Dhabi 127788, U Arab Emirates

[5] Univ Malaga, IBIMA Biomed Res Inst Malaga BIONAND Platform, Andalucia Tech, Dept Mol Biol & Biochem,Fac Sci, Malaga 29590, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期

基金：

欧洲研究理事会;

关键词：

tumor microenvironment; tumor angiogenesis; tumor endothelial cell metabolism; metabolic reprogramming; FACTOR RECEPTOR 2; IN-VIVO; VESSEL NORMALIZATION; VASCULAR MIMICRY; GENE-EXPRESSION; ANGIOGENESIS; CANCER; ACID; GLUTAMINE; INHIBITION;

D O I：

10.3390/ijms231911052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute to hypoxia and acidosis in the tumor microenvironment. In this hostile environment, cancer and stromal cells have the ability to alter their metabolism in order to support the high energetic demands and favor rapid tumor proliferation. Recent advances have shown that tumor endothelial cell metabolism is reprogrammed, and that targeting endothelial metabolic pathways impacts developmental and pathological vessel sprouting. Therefore, the use of metabolic antiangiogenic therapies to normalize the blood vasculature, in combination with immunotherapies, offers a clinical niche to treat cancer.

引用

页数：19

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