The combined effect of Sango sprout juice and caloric restriction on metabolic disorders and gut microbiota composition in an obesity model

被引:10
作者
Vivarelli, Fabio [1 ]
Canistro, Donatella [1 ]
Marquillas, Clara Babot [1 ]
Cirillo, Silvia [1 ]
De Nicola, Gina R. [2 ]
Iori, Renato [2 ]
Biagi, Giacomo [3 ]
Pinna, Carlo [3 ]
Gentilini, Fabio [3 ]
Pozzo, Luisa [4 ]
Longo, Vincenzo [4 ]
Paolini, Moreno [1 ]
机构
[1] Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, Via Irnerio 48, I-40126 Bologna, Italy
[2] Ctr Ric Agr & Ambiente CREA AA, Consiglio Ric Agr & Anal Econ Agr, Bologna, Italy
[3] Alma Mater Studiorum Univ Bologna, Dept Vet Med Sci, Bologna, Italy
[4] CNR, Inst Agr Biol & Biotechnol, Pisa, Italy
关键词
Raphanus sativus; Sango; antioxidants; anti-obesity; microbiota; SATIVUS CV SANGO; HIGH-FAT DIET; TUSCAN BLACK CABBAGE; GLUTATHIONE-PEROXIDASE; ACYLATED ANTHOCYANINS; SUPEROXIDE-DISMUTASE; IN-VITRO; ENZYMES; CYTOCHROME-P450; ANTIOXIDANT;
D O I
10.1080/09637486.2017.1350940
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The main purpose of this study was to compare the benefits of SSJ supplementation in obese rats with those achieved only by switching the alimentary regimen from high-fat (HFD) to the regular one (RD) in liver, ileum and prostate. Furthermore, changings in caecal chime microbiota were investigated. SSJ was administered to rats in combination with a RD (HFD-RD+SSJ). The switch from HFD to RD led to a weight loss of almost 9.8g, and the total cholesterol was found to be significantly lower. In the HFD-RD+SSJ group, all values were improved compared with the HFD control, and the weight decrement was higher (-23.29g) with respect to HFD-RD. HFD led to a widespread increment of oxidative stress (OS) markers in liver, ileum and prostate. SSJ has shown to improve the results achieved by the suspension of HFD and it has proven effective wherever the only switch in diet regimen failed.
引用
收藏
页码:192 / 204
页数:13
相关论文
共 68 条
[1]   Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis [J].
Abdelmegeed, Mohamed A. ;
Banerjee, Atrayee ;
Yoo, Seong-Ho ;
Jang, Sehwan ;
Gonzalez, Frank J. ;
Song, Byoung-Joon .
JOURNAL OF HEPATOLOGY, 2012, 57 (04) :860-866
[2]   SIMPLE AND SENSITIVE ASSAY OF 7-ETHOXYCOUMARIN DEETHYLATION [J].
AITIO, A .
ANALYTICAL BIOCHEMISTRY, 1978, 85 (02) :488-491
[3]   Obesity: The preventive role of the pomegranate (Punica granatum) [J].
Al-Muammar, May Nasser ;
Khan, Fozia .
NUTRITION, 2012, 28 (06) :595-604
[4]   Enumeration of total bacteria and bacteria with genes for proteolytic activity in pure cultures and in environmental samples by quantitative PCR mediated amplification [J].
Bach, HJ ;
Tomanova, J ;
Schloter, M ;
Munch, JC .
JOURNAL OF MICROBIOLOGICAL METHODS, 2002, 49 (03) :235-245
[5]   Harmful effects behind the daily supplementation of a fixed vegetarian blend in the rat model [J].
Bonamassa, Barbara ;
Canistro, Donatella ;
Sapone, Andrea ;
Vivarelli, Fabio ;
Vornoli, Andrea ;
Longo, Vincenzo ;
Paolini, Moreno .
FOOD AND CHEMICAL TOXICOLOGY, 2016, 97 :367-374
[6]   ETHOXYPHENOXAZONES, PENTOXYPHENOXAZONES, AND BENZYLOXYPHENOXAZONES AND HOMOLOGS - A SERIES OF SUBSTRATES TO DISTINGUISH BETWEEN DIFFERENT INDUCED CYTOCHROMES-P-450 [J].
BURKE, MD ;
THOMPSON, S ;
ELCOMBE, CR ;
HALPERT, J ;
HAAPARANTA, T ;
MAYER, RT .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (18) :3337-3345
[7]   Alteration of xenobiotic metabolizing enzymes by resveratrol in liver and lung of CD1 mice [J].
Canistro, D. ;
Bonamassa, B. ;
Pozzetti, L. ;
Sapone, A. ;
Abdel-Rahman, S. Z. ;
Biagi, G. L. ;
Paolini, M. .
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (02) :454-461
[8]   Digestibility, toxicity and metabolic effects of rapeseed and sunflower protein hydrolysates in mice [J].
Canistro, Donatella ;
Vivarelli, Fabio ;
Ugolini, Luisa ;
Pinna, Carlo ;
Grandi, Monica ;
Antonazzo, Ippazio Cosimo ;
Cirillo, Silvia ;
Sapone, Andrea ;
Cinti, Susanna ;
Lazzeri, Luca ;
Conte, Emanuele ;
Biagi, Giacomo .
ITALIAN JOURNAL OF ANIMAL SCIENCE, 2017, 16 (03) :462-473
[9]   Comparison between in toto peach (Prunus persica L. Batsch) supplementation and its polyphenolic extract on rat liver xenobiotic metabolizing enzymes [J].
Canistro, Donatella ;
Vivarelli, Fabio ;
Cirillo, Silvia ;
Costa, Guglielmo ;
Andreotti, Carlo ;
Paolini, Moreno .
FOOD AND CHEMICAL TOXICOLOGY, 2016, 97 :385-394
[10]   Black cabbage seed extract affects rat Cyp-mediated biotransformation: Organ and sex related differences [J].
Canistro, Donatella ;
Barillari, Jessica ;
Melega, Simone ;
Sapone, Andrea ;
Iori, Renato ;
Speroni, Ester ;
Paolini, Moreno .
FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (08) :2612-2621