Human milk oligosaccharides: Shaping the infant gut microbiota and supporting health

被引:215
作者
Walsh, Clodagh [1 ,2 ,3 ,4 ]
Lane, Jonathan A. [2 ]
van Sinderen, Douwe [3 ,4 ]
Hickey, Rita M. [1 ]
机构
[1] Teagasc Food Res Ctr, Moorepk, Fermoy P61C996, Cork, Ireland
[2] Global Res & Technol Ctr, H&H Grp, Cork P61 C996, Cork, Ireland
[3] Natl Univ Ireland, APC Microbiome Inst, Cork, Ireland
[4] Natl Univ Ireland, Sch Microbiol, Cork, Ireland
基金
爱尔兰科学基金会;
关键词
Human milk oligosaccharides; Prebiotics; Breast milk; Gut health; BLOOD GROUP ANTIGENS; CHAIN FATTY-ACIDS; LACTO-N-BIOSE; IN-VITRO; SIALIC-ACID; ROTAVIRUS INFECTIVITY; NOROVIRUS INHIBITION; COLONIC MICROBIOTA; ESCHERICHIA-COLI; CACO-2; CELLS;
D O I
10.1016/j.jff.2020.104074
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Human milk oligosaccharides (HMO) are complex sugars which are found in breast milk at significant concentrations and with unique structural diversity. These sugars are the fourth most abundant component of human milk after water, lipids, and lactose and yet provide no direct nutritional value to the infant. Recent research has highlighted that HMOs have various functional roles to play in infant development. These sugars act as prebiotics by promoting growth of beneficial intestinal bacteria thereby generating short-chain fatty acids which are critical for gut health. HMOs also directly modulate host-epithelial immune responses and can selectively reduce binding of pathogenic bacteria and viruses to the gut epithelium preventing the emergence of a disease. This review covers current knowledge related to the functional biology of HMOs and their associated impact on infant gut health.
引用
收藏
页数:13
相关论文
共 145 条
[111]   Human milk oligosaccharides and development of cow's milk allergy in infants [J].
Seppo, Antti E. ;
Autran, Chloe A. ;
Bode, Lars ;
Jaervinen, Kirsi M. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (02) :708-+
[112]   Identifying human milk glycans that inhibit norovirus binding using surface plasmon resonance [J].
Shang, Jing ;
Piskarev, Vladimir E. ;
Xia, Ming ;
Huang, Pengwei ;
Jiang, Xi ;
Likhosherstov, Leonid M. ;
Novikova, Olga S. ;
Newburg, David S. ;
Ratner, Daniel M. .
GLYCOBIOLOGY, 2013, 23 (12) :1491-1498
[113]   A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis [J].
Shirley, Debbie-Ann T. ;
Farr, Laura ;
Watanabe, Koji ;
Moonah, Shannon .
OPEN FORUM INFECTIOUS DISEASES, 2018, 5 (07)
[114]   Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides [J].
Simon, PM ;
Goode, PL ;
Mobasseri, A ;
Zopf, D .
INFECTION AND IMMUNITY, 1997, 65 (02) :750-757
[115]   Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate [J].
Smilowitz, Jennifer T. ;
Lebrilla, Carlito B. ;
Mills, David A. ;
German, J. Bruce ;
Freeman, Samara L. .
ANNUAL REVIEW OF NUTRITION, VOL 34, 2014, 34 :143-169
[116]  
Sotgiu S, 2006, Int J Biomed Sci, V2, P114
[117]   The Role of Short-Chain Fatty Acids in Health and Disease [J].
Tan, Jian ;
McKenzie, Craig ;
Potamitis, Maria ;
Thorburn, Alison N. ;
Mackay, Charles R. ;
Macia, Laurence .
ADVANCES IN IMMUNOLOGY, VOL 121, 2014, 121 :91-119
[118]   The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis [J].
Tarr, Andrew J. ;
Galley, Jeffrey D. ;
Fisher, Sydney E. ;
Chichlowski, Maciej ;
Berg, Brian M. ;
Bailey, Michael T. .
BRAIN BEHAVIOR AND IMMUNITY, 2015, 50 :166-177
[119]   Virus recognition of glycan receptors [J].
Thompson, Andrew J. ;
de Vries, Robert P. ;
Paulson, James C. .
CURRENT OPINION IN VIROLOGY, 2019, 34 :117-129
[120]   Human milk oligosaccharides and infant gut bifidobacteria: Molecular strategies for their utilization [J].
Thomson, Pamela ;
Medina, Daniel A. ;
Garrido, Daniel .
FOOD MICROBIOLOGY, 2018, 75 :37-46