Development of Controlled-Release Formulation to Improve Bioavailability of Esomeprazole

被引:0
作者
Soujanya, C. [1 ,2 ]
Satya, B. Lakshmi [1 ]
Marepally, Chandrika [1 ]
Vinjamuri, Bhavya Sri [1 ]
Ettadi, Rupika Reddy [1 ]
机构
[1] Vishnu Inst Pharmaceut Educ & Res, Dept Pharmaceut, Narsapur, Telangana, India
[2] Vishnu Inst Pharmaceut Educ & Res, Dept Pharmaceut, Medak, Telangana, India
关键词
Bioavailability; esomeprazole; oral drug delivery system;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Aim: The aim of this study was to release the active drug immediately after oral administration, to acquire quick, and enter systemic drug absorption. Such immediate-release products result in comparatively rapid drug absorption and onset of associated pharmacodynamic effects. Materials and Methods: The prepared esomeprazole CR tablets were evaluated for the dissolution studies in acid buffer (pH-1.2) for 2 h, 4.5 pH acetate buffers for 2 h, 6.8 pH phosphate buffers for 8 h, and 7.4 pH phosphate buffers for 12 h % drug release that was calculated at various time intervals. Results and Discussion: The present study was aimed to developing controlled-release tablets of esomeprazole using various polymers. All the formulations were evaluated for physicochemical properties and in vitro drug release studies. Conclusion: The current research work envisaged was an attempt to development of controlled-release formulations of esomeprazole to improve bioavailability.
引用
收藏
页码:471 / 477
页数:7
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