Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine

被引：131

作者：

Moledina, Dennis G. ^{[1
]}

Parikh, Chirag R. ^{[2
]}

机构：

[1] Yale Sch Med, Dept Internal Med, Sect Nephrol, Program Appl Translat Res, New Haven, CT USA

[2] VA Connecticut Healthcare Syst, West Haven, CT USA

来源：

SEMINARS IN NEPHROLOGY | 2018年 / 38卷 / 01期

基金：

美国国家卫生研究院;

关键词：

AKI; biomarkers; creatinine; cystatin C; NGAL; IL-18; KIM-1; L-FABP; IL-6; furosemide; urine microscopy; urinary casts; LONG-TERM SURVIVAL; URINARY BIOMARKERS; DIFFERENTIAL-DIAGNOSIS; GENE-EXPRESSION; ISCHEMIC-INJURY; POOR OUTCOMES; CYSTATIN C; AKI; DEFINITIONS; MORTALITY;

D O I：

10.1016/j.semnephrol.2017.09.002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute kidney injury (AKI) is a common complication in hospitalized patients and is associated with adverse short- and long-term outcomes. AKI is diagnosed by serum creatinine (SCr)-based consensus definitions that capture an abrupt decrease in glomerular filtration rate associated with AKI. However, SCr-based AKI definitions lack sensitivity and specificity for diagnosing structural kidney injury. Moreover, AKI is a heterogeneous condition consisting of distinct phenotypes based on its etiology, prognosis, and molecular pathways, and that may potentially require different therapies. SCr-based AKI definitions provide no information on these AKI phenotypes. This review highlights traditional and novel tools that overcome the limitations of SCr-based AKI definitions to improve AKI phenotyping. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：3 / 11

页数：9

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