Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7

被引：29

作者：

Yanagida, Takashi ^{[1
]}

Kitamura, Yoshihisa ^{[1
]}

Yamane, Koichiro ^{[1
]}

Takahashi, Kazunori ^{[3
]}

Takata, Kazuyuki ^{[1
]}

Yanagisawa, Daijiro ^{[1
]}

Yasui, Hiroyuki ^{[2
]}

Taniguchi, Takashi ^{[1
]}

Taira, Takahiro ^{[4
]}

Honda, Toshio ^{[3
]}

Ariga, Hiroyoshi ^{[5
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Neurobiol, Kyoto 6078414, Japan

[2] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Kyoto 6078414, Japan

[3] Hoshi Univ, Fac Pharmaceut Sci, Tokyo 1428501, Japan

[4] Univ Yamanashi, Dept Mol Cell Biol, Interdisciplinary Grad Sch Med & Engn, Chuo 4093898, Japan

[5] Hokkaido Univ, Dept Mol Biol, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2009年 / 109卷 / 03期

关键词：

DJ-1; modulator; anti-oxidative effect; neuroprotection; CELL-DEATH; RAT MODEL; PROTEIN; APOPTOSIS;

D O I：

10.1254/jphs.08323SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although a loss-of-function type mutation was identified in familial Parkinson's disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the neuroprotective effects of UCP0054278 against focal ischemia-induced neurodegeneration in rats. Hydrogen peroxide-induced cell death and the production of reactive oxygen species were significantly inhibited by UCP0054278 in normal SH-SY5Y cells, but not in DJ-1-knockdown cells. These results suggest that UCP0054278 interacts with endogenous DJ-1 and then exhibits antioxidant and neuroprotective responses.

引用

页码：463 / 468

页数：6

共 16 条

[1] PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke [J].

Allard, L ;

Burkhard, PR ;

Lescuyer, P ;

Burgess, JA ;

Walter, N ;

Hochstrasser, DF ;

Sanchez, JC .

CLINICAL CHEMISTRY, 2005, 51 (11) :2043-2051

[2] Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].

Bonifati, V ;

Rizzu, P ;

van Baren, MJ ;

Schaap, O ;

Breedveld, GJ ;

Krieger, E ;

Dekker, MCJ ;

Squitieri, F ;

Ibanez, P ;

Joosse, M ;

van Dongen, JW ;

Vanacore, N ;

van Swieten, JC ;

Brice, A ;

Meco, G ;

van Duijn, CM ;

Oostra, BA ;

Heutink, P .

SCIENCE, 2003, 299 (5604) :256-259

[3] DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 [J].

Clements, Casey M. ;

McNally, Richard S. ;

Conti, Brian J. ;

Mak, Tak W. ;

Ting, Jenny P-Y. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (41) :15091-15096

[4] PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model [J].

Inden, Masatoshi ;

Taira, Takahiro ;

Kitamura, Yoshihisa ;

Yanagida, Takashi ;

Tsuchiya, Daiju ;

Takata, Kazuyuki ;

Yanagisawa, Daijiro ;

Nishimura, Kaneyasu ;

Taniguchi, Takashi ;

Kiso, Yoshiaki ;

Yoshimoto, Kanji ;

Agatsuma, Tomohiro ;

Koide-Yoshida, Shizuyo ;

Iguchi-Ariga, Sanae M. M. ;

Shimohama, Shun ;

Ariga, Hiroyoshi .

NEUROBIOLOGY OF DISEASE, 2006, 24 (01) :144-158

[5] Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death [J].

Junn, E ;

Taniguchi, H ;

Jeong, BS ;

Zhao, X ;

Ichijo, H ;

Mouradian, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (27) :9691-9696

[6] Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells [J].

Kinumi, T ;

Kimata, J ;

Taira, T ;

Ariga, H ;

Niki, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 317 (03) :722-728

[7] DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats [J].

Miyazaki, Shin ;

Yanagida, Takashi ;

Nunome, Kana ;

Ishikawa, Shizuma ;

Inden, Masatoshi ;

Kitamura, Yoshihisa ;

Nakagawa, Shinsuke ;

Taira, Takahiro ;

Hirota, Kosaku ;

Niwa, Masami ;

Iguchi-Ariga, Sanae M. M. ;

Ariga, Hiroyoshi .

JOURNAL OF NEUROCHEMISTRY, 2008, 105 (06) :2418-2434

[8] DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras [J].

Nagakubo, D ;

Taira, T ;

Kitaura, H ;

Ikeda, M ;

Tamai, K ;

IguchiAriga, SMM ;

Ariga, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 231 (02) :509-513

[9] DJ-1 interacts with HIPK1 and affects H2O2-induced cell death [J].

Sekito, A ;

Koide-Yoshida, S ;

Niki, T ;

Taira, T ;

Iguchi-Ariga, SMM ;

Ariga, H .

FREE RADICAL RESEARCH, 2006, 40 (02) :155-165

[10] DJ-1 has a role in antioxidative stress to prevent cell death [J].

Taira, T ;

Saito, Y ;

Niki, T ;

Iguchi-Ariga, SMM ;

Takahashi, K ;

Ariga, H .

EMBO REPORTS, 2004, 5 (02) :213-218

← 1 2 →