Correlation between plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G polymorphism and metabolic/proinflammatory factors in polycystic ovary syndrome

被引：18

作者：

Sales, M. F. ^{[1
,2
]}

Soter, M. O. ^{[1
]}

Candido, A. L. ^{[3
]}

Fernandes, A. P. ^{[1
,2
]}

Oliveira, F. R. ^{[3
]}

Ferreira, A. C. S. ^{[5
]}

Sousa, M. O. ^{[1
]}

Ferreira, C. N. ^{[4
]}

Gomes, K. B. ^{[1
,2
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Colegio Tecn, BR-31270901 Belo Horizonte, MG, Brazil

[5] Inst Hermes Pardini, Belo Horizonte, MG, Brazil

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2013年 / 29卷 / 10期

关键词：

LAP; PAI-1; polycystic ovary syndrome; VCAM; vitamin D; ADHESION MOLECULE-1; METABOLIC SYNDROME; VITAMIN-D; WOMEN; PREVENTION; EXPRESSION; OBESITY; DISEASE; YOUNG;

D O I：

10.3109/09513590.2013.819086

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic Ovary Syndrome (PCOS) is the most common cause of subfertility associated to metabolic disorders. The aim of this study was to correlate metabolic and proinflammatory factors in women with PCOS. The frequency of Plasminogen Activator Inhibitor-1 (PAI-1) promoter 4 G/5 G polymorphism was also compared to healthy controls. We evaluated 79 PCOS and 79 healthy women. PAI-1 levels are positively correlated with proinflammatory factors in PCOS group. 4 G allele in PAI-1 gene was more frequent in PCOS and the 4G/4 G genotype was associated with increased PAI-1 levels. A correlation between insulin resistance and proinflammatory and overweight was also observed. C-reactive protein, serum levels of vascular cell adhesion molecule-1 (sVCAM-1), Lipid Accumulation Product (LAP) and vitamin D are good tools to evaluated factors associated to cardiovascular risk in women with PCOS.

引用

页码：936 / 939

页数：4

共 29 条

[1] Plasminogen activator inhibitor-1 4G/5G polymorphism is associated with metabolic syndrome parameters in Malaysian subjects [J].

Al-Hamodi, Zaid H. ;

Saif-Ali, Riyadh ;

Ismail, Ikram S. ;

Ahmed, Khaled A. ;

Muniandy, Sekaran .

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2012, 50 (03) :184-189

[2]

Grundy Scott M, 2005, Crit Pathw Cardiol, V4, P198

[3]

[Anonymous], 1994, CIRCULATION, V89, P1333, DOI [DOI 10.1161/01.CIR.89.3.1333, 10.1161/01.CIR.89.3.1333]

[4] The prevalence and features of the polycystic ovary syndrome in an unselected population [J].

Azziz, R ;

Woods, KS ;

Reyna, R ;

Key, TJ ;

Knochenhauer, ES ;

Yildiz, BO .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2745-2749

[5] Introduction [J].

Cheng, Alice Y. Y. .

CANADIAN JOURNAL OF DIABETES, 2013, 37 :S1-S3

[6] Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants [J].

Cook-Mills, Joan M. ;

Marchese, Michelle E. ;

Abdala-Valencia, Hiam .

ANTIOXIDANTS & REDOX SIGNALING, 2011, 15 (06) :1607-1638

[7] Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis [J].

Escobar-Morreale, Hector F. ;

Luque-Ramirez, Manuel ;

Gonzalez, Frank .

FERTILITY AND STERILITY, 2011, 95 (03) :1048-U249

[8] Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [J].

Fauser, BCJM ;

Chang, J ;

Azziz, R ;

Legro, R ;

Dewailly, D ;

Franks, S ;

Tarlatzis, BC ;

Fauser, B ;

Balen, A ;

Bouchard, P ;

Dahlgren, E ;

Devoto, L ;

Diamanti, E ;

Dunaif, A ;

Filicori, M ;

Homburg, R ;

Ibanez, L ;

Laven, J ;

Magoffin, D ;

Nestler, J ;

Norman, RJ ;

Pasquali, R ;

Pugeat, M ;

Strauss, J ;

Tan, S ;

Taylor, A ;

Wild, R ;

Wild, S ;

Ehrmann, D ;

Lobo, R .

HUMAN REPRODUCTION, 2004, 19 (01) :41-47

[9] 4G/5G polymorphism modulates PAI-1 circulating levels in obese women [J].

Fernandes, Karla S. ;

Sandrim, Valeria C. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 364 (1-2) :299-301

[10] Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline [J].

Holick, Michael F. ;

Binkley, Neil C. ;

Bischoff-Ferrari, Heike A. ;

Gordon, Catherine M. ;

Hanley, David A. ;

Heaney, Robert P. ;

Murad, M. Hassan ;

Weaver, Connie M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (07) :1911-1930

← 1 2 3 →