3-Keto steroids from the marine organisms Dendrophyllia cornigera and Cymodocea nodosa

被引：55

作者：

Kontiza, I ^{[1
]}

Abatis, D ^{[1
]}

Malakate, K ^{[1
]}

Vagias, C ^{[1
]}

Roussis, V ^{[1
]}

机构：

[1] Univ Athens, Dept Pharm, Div Pharmacognosy & Chem Nat Prod, GR-15771 Athens, Greece

来源：

STEROIDS | 2006年 / 71卷 / 02期

关键词：

3-keto steroids; cytotoxicity; Cymodocea nodosa; Dendophyllia cornigera;

D O I：

10.1016/j.steroids.2005.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new (20R)-22E-cholesta-4,22-diene-3,6-dione (1), along with three known 3-keto steroids were isolated from the deep-water Mediterranean scleractinian coral Dendrophyllia cornigera (2-4). Moreover, four known related 3-keto steroids were isolated from the sea grass Cymodocea nodosa (5-8). The structure elucidation of steroid 1 and the full NMR resonance assignments of all isolated metabolites were based on interpretation of their spectral data. All compounds are reported for the first time as metabolites of the investigated organisms. Compounds 2 and 3 showed significant cytotoxicity against lung cancer NSCLC-N6 cell line. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：177 / 181

页数：5

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