Synthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazolea novel fused indazole derivative

被引：0

作者：

Gopalakrishnan, M. ^{[1
]}

Sureshkumar, P. ^{[1
]}

Thanusu, J. ^{[1
]}

Kanagarajan, V. ^{[1
]}

机构：

[1] Annamalai Univ, Dept Chem, Synthet Organ Chem Lab, Annamalainagar 608002, Tamil Nadu, India

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2008年 / 23卷 / 06期

关键词：

6-Carbethoxy-3; 5-diarylcyclohex-2-enone; 4; 6-diaryl-4; 5-dihydro-3-hydroxy-2[H]-indazole; hydrazine hydrate; antibacterial activity; antifungal activity;

D O I：

10.1080/14756360701811254

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel class of 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazoles 25-32 were synthesized and evaluated for their in vitro antibacterial and antifungal activities. Four Compounds, which all possessed electron withdrawing functional groups (-Cl, -NO2, -Br) 27, 28, 30 and 32 were more potent against the tested bacterial/fungal strains than the standard bacterial and fungal drugs ciprofloxacin and fluconazole respectively.

引用

页码：974 / 979

页数：6

共 16 条

[1] Synthesis and antibacterial activity of some 5-(4-biphenylyl)-7-aryl [3,4-d]-1,2,3-benzoselenadiazoles
Balasankar, T.
Gopalakrishnan, M.
Nagarajan, S.
[J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2007, 22 (02) : 171 - 175
[2] Synthesis and antibacterial activity of some 5-(4-biphenylyl)-7-aryl[3,4-d] [1,2,3]-benzothiadiazoles
Balasankar, T
Gopalakrishnan, M
Nagarajan, S
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (07) : 728 - 731
[3] STUDIES ON REDUCTION OF SOME SUBSTITUTED CYCLOHEXANONES
BALASUBRAMANIAN, M
DSOUZA, A
[J]. TETRAHEDRON, 1968, 24 (15) : 5399 - +
[4] CECCHI L, 1984, FARMACO-ED SCI, V39, P945
[5] DHAR ML, 1968, INDIAN J EXP BIOL, V6, P232
[6] Indazole N-oxide derivatives as antiprotozoal agents:: Synthesis, biological evaluation and mechanism of action studies
Gerpe, A
Aguirre, G
Boiani, L
Cerecetto, H
González, M
Olea-Azar, C
Rigol, C
Maya, JD
Morello, A
Piro, OE
Arán, VJ
Azqueta, A
de Ceráin, AL
Monge, A
Rojas, MA
Yaluff, G
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (10) : 3467 - 3480
[7] Gopalakrishnan M, 2007, J CHEM RES, P80
[8] Gopalakrishnan M., 2007, J SULFUR CHEM, V28, P383
[9] GOPALAKRISHNAN M, 2007, J ENZ INHIB IN PRESS
[10] THE ALDOL CONDENSATION OF ACETOPHENONE WITH ACETONE
GUTHRIE, JP
WANG, XP
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1991, 69 (02): : 339 - 344

← 1 2 →