Neurotrophins: To cleave or not to cleave

被引：230

作者：

Chao, MV ^{[1
]}

Bothwell, M

机构：

[1] NYU, Sch Med, Mol Neurobiol Program, Skirball Inst Biomol Med,Dept Cell Biol, New York, NY 10016 USA

[2] NYU, Sch Med, Mol Neurobiol Program, Skirball Inst Biomol Med,Dept Physiol, New York, NY 10016 USA

[3] NYU, Sch Med, Mol Neurobiol Program, Skirball Inst Biomol Med,Dept Neurosci, New York, NY 10016 USA

[4] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

NEURON | 2002年 / 33卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(01)00573-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The family of neurotrophic factors known as neurotrophins has yielded a series of surprises, both with regard to the broad extent of their functional roles and the remarkable complexity of their signaling mechanisms. The recent discovery that a neurotrophin precursor protein and its proteolytically processed products may differentially activate pro- and antiapoptotic cellular responses, through preferential activation of Trk or p75 receptors, promises to unveil yet another level of regulatory complexity.

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页码：9 / 12

页数：4

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