Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging

被引：124
|
作者：
Ma, Ping'an [1 ]
Xiao, Haihua [3 ]
Li, Xiaoxue [4 ]
Li, Chunxia [1 ]
Dai, Yunlu [1 ,2 ]
Cheng, Ziyong [1 ]
Jing, Xiabin [5 ]
Lin, Jun [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 10049, Peoples R China
[3] Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA
[4] NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China
[5] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 35期
基金：
中国国家自然科学基金;
关键词：
biomedical imaging; cisplatin; drug delivery; self-assembly; upconversion fluorescent; ANTICANCER DRUG; IN-VIVO; CAENORHABDITIS-ELEGANS; TOXICITY ASSESSMENTS; POROUS NAYF4/YB3+; C-ELEGANS; NANOPARTICLES; CELL; LUMINESCENT; PACLITAXEL;
D O I：
10.1002/adma.201301713
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4898 / 4905
页数：8
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