International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

被引：116

作者：

Brat, Gabriel A. ^{[1
]}

Weber, Griffin M. ^{[1
]}

Gehlenborg, Nils ^{[1
]}

Avillach, Paul ^{[1
]}

Palmer, Nathan P. ^{[1
]}

Chiovato, Luca ^{[2
,3
]}

Cimino, James ^{[4
]}

Waitman, Lemuel R. ^{[5
]}

Omenn, Gilbert S. ^{[6
]}

Malovini, Alberto ^{[2
]}

Moore, Jason H. ^{[7
,8
]}

Beaulieu-Jones, Brett K. ^{[1
]}

Tibollo, Valentina ^{[2
]}

Murphy, Shawn N. ^{[9
]}

L'Yi, Sehi ^{[1
]}

Keller, Mark S. ^{[1
]}

Bellazzi, Riccardo ^{[2
,10
]}

Hanauer, David A. ^{[11
]}

Serret-Larmande, Arnaud ^{[1
]}

Gutierrez-Sacristan, Alba ^{[1
]}

Holmes, John J. ^{[7
,11
]}

Bell, Douglas S. ^{[12
]}

Mandl, Kenneth D. ^{[13
]}

Follett, Robert W. ^{[12
]}

Klann, Jeffrey G. ^{[14
]}

Murad, Douglas A. ^{[12
]}

Scudeller, Luigia ^{[15
]}

Bucalo, Mauro ^{[16
]}

Kirchoff, Katie ^{[17
]}

Craig, Jean ^{[17
]}

Obeid, Jihad ^{[17
]}

Jouhet, Vianney ^{[18
]}

Griffier, Romain ^{[18
]}

Cossin, Sebastien ^{[18
]}

Moal, Bertrand ^{[18
]}

Patel, Lav P. ^{[5
]}

Bellasi, Antonio ^{[19
]}

Prokosch, Hans U. ^{[20
]}

Kraska, Detlef ^{[21
]}

Sliz, Piotr ^{[13
]}

Tan, Amelia L. M. ^{[1
]}

Ngiam, Kee Yuan ^{[22
]}

Zambelli, Alberto ^{[23
]}

Mowery, Danielle L. ^{[7
,11
]}

Schiver, Emily ^{[24
]}

Devkota, Batsal ^{[25
]}

Bradford, Robert L. ^{[26
]}

Daniar, Mohamad ^{[13
]}

Daniel, Christel ^{[27
]}

Benoit, Vincent ^{[27
]}

机构：

[1] Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA

[2] IRCCS Maugeri, Pavia, Italy

[3] Univ Pavia, Dept Internal Med & Med Therapy, Pavia, Italy

[4] UAB, Informat Inst, Birmingham, AL USA

[5] Univ Kansas, Med Ctr, Div Med Informat, Dept Internal Med, Kansas City, KS 66103 USA

[6] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[7] Univ Penn, Perelman Sch Med, Inst Biomed Informat, Philadelphia, PA 19104 USA

[8] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

[9] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[10] Univ Pavia, Dept Elect Comp & Biomed Engn, Pavia, Italy

[11] Univ Michigan, Sch Med, Dept Pediat, Ann Arbor, MI USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[13] Boston Childrens Hosp, Computat Hlth Informat Program, Boston, MA USA

[14] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[15] IRCCS Ca Granda Osped Maggiore Policlin Milano, Sci Direct, Milan, Italy

[16] BIOMERIS BioMed Res Informat Solut, Pavia, Italy

[17] Med Univ South Carolina, Biomed Informat Ctr, Charleston, SC 29425 USA

[18] Bordeaux Univ Hosp, Bordeaux, France

[19] ASST Papa Giovanni XXIII, UOC Ric Innovaz & Brand Reputat, Bergamo, Italy

[20] Univ Erlangen Nurnberg, Dept Med Informat, Erlangen, Germany

[21] Univ Hosp Erlangen, Ctr Med Informat & Commun Technol, Erlangen, Germany

[22] Natl Univ Hlth Syst, Singapore, Singapore

[23] ASST Papa Giovanni XXIII, Dept Oncol, Bergamo, Italy

[24] Penn Med, Data Analyt Ctr, Philadelphia, PA USA

[25] Childrens Hosp Philadelphia, Dept Biomed & Hlth Informat, Philadelphia, PA 19104 USA

[26] Univ N Carolina, North Carolina Translat & Clin Sci NC TraCS, Chapel Hill, NC USA

[27] WIND Dept APHP Greater Paris Univ Hosp, Paris, France

[28] Greater Paris Univ Hosp, APHP, HEGP, Dept Biomed Informat, Paris, France

[29] Greater Paris Univ Hosp, APHP, Clin Res Unit, St Antoine Hosp, Paris, France

[30] Greater Paris Univ Hosp, APHP, Strategy & Transformat Dept, Paris, France

[31] Heidelberg Univ, Univ Med Mannheim, Heinrich Lanz Ctr Digital Hlth, Mannheim, Germany

[32] INRIA Sophia Antipolis, LIRMM, ZENITH Team, Montpellier, France

[33] Univ Freiburg, Inst Med Biometry & Stat, Med Ctr, Freiburg, Germany

[34] Greater Paris Univ Hosp, APHP, Paris Saclay, Clin Res Unit, Paris, France

[35] Inria Ctr Paris, SED SIERRA, Paris, France

[36] Univ Paris Saclay, Inria, CEA, Paris, France

[37] Clevy Io, Paris, France

[38] SequeL, Inria Lille, Paris, France

[39] PSL Univ, ENS, Paris, France

[40] Univ Freiburg, Inst Digitalizat Med, Fac Med, Freiburg, Germany

[41] Univ Freiburg, Med Ctr, Freiburg, Germany

[42] IRCCS Ca Granda Osped Maggiore Policlin Milano, Milan, Italy

[43] Wake Forest Sch Med, Brenner Childrens Hosp, Winston Salem, NC 27101 USA

来源：

NPJ DIGITAL MEDICINE | 2020年 / 3卷 / 01期

关键词：

INTEGRATING BIOLOGY; INFORMATICS; CARE;

D O I：

10.1038/s41746-020-00308-0

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.

引用

页数：9

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