Design of guanidinium porphyrins as potential G-quadruplex ligands

被引：3

作者：

Xu, Hai-Jun ^{[1
]}

Richard, Philippe ^{[1
]}

Barbe, Jean-Michel ^{[1
]}

Gros, Claude P. ^{[1
]}

机构：

[1] Univ Bourgogne, ICMUB UMR 6302, F-21078 Dijon, France

来源：

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES | 2012年 / 16卷 / 10期

关键词：

G-quadruplex ligands; amino-acid porphyrins; guanidinium functionalities; TELOMERIC G-QUADRUPLEX; DISPLACEMENT ASSAY; SMALL-MOLECULE; C-MYC; DNA; BINDING; RECOGNITION; INHIBITOR; SEQUENCE; STABILIZATION;

D O I：

10.1142/S108842461250109X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein an easy and smooth synthesis of two novel tetra-meso-substituted porphyrins bearing terminal guanidinium functionalities. These two guanidine derivatives are the porphyrin-based analogs of ZnPC, a closely related phthalocyanine-based molecule with four guanidinium arms already reported as an efficient G-quadruplex ligand.

引用

页码：1073 / 1081

页数：9

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