Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury

被引：35

作者：

Bitzer, Markus ^{[1
]}

Ben-Dov, Iddo Z. ^{[2
]}

Thum, Thomas ^{[3
,4
]}

机构：

[1] Univ Michigan, Div Nephrol, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10021 USA

[3] Hannover Med Sch, Inst Mol & Translat Therapeut Strategies, D-3000 Hannover, Germany

[4] IRCCS San Raffaele, Ctr Clin & Basic Res, Rome, Italy

来源：

KIDNEY INTERNATIONAL | 2012年 / 82卷 / 04期

关键词：

D O I：

10.1038/ki.2012.152

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Horizontal information transfer between cells via microparticles is a newly identified communication system. MicroRNAs regulate gene expression and are detected in microparticles. Cantaluppi et al. suggest that microparticles derived from circulating angiogenic cells-'endothelial progenitor cells' (EPCs)-harbor endothelial-protective miRNAs such as miR-126 and that delivery of EPC-derived microparticles during acute kidney ischemia-reperfusion in rats ameliorates kidney dysfunction and damage. We highlight the importance, potential future impact, and limitations of this study. Kidney International (2012) 82, 375-377. doi:10.1038/ki.2012.152

引用

页码：375 / 377

页数：3

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