An improved synthesis of 5′-amino-5′-deoxyguanosine

被引：22

作者：

Dean, DK ^{[1
]}

机构：

[1] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 10期

关键词：

D O I：

10.1081/SCC-120004140

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient three step synthesis of 5'-amino-5'-deoxyguanosine 1 from guanosine 2 is reported.

引用

页码：1517 / 1521

页数：5

共 11 条

[1] INHIBITORS OF GDP MANNOSE DEHYDROGENASE OF PSEUDOMONAS-AERUGINOSA MUCOID STRAINS [J].

ELLOUMI, N ;

MOREAU, B ;

AGUIAR, L ;

JAZIRI, N ;

SAUVAGE, M ;

HULEN, C ;

CAPMAU, ML .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (02) :149-154

[2] DESIGN AND SYNTHESIS OF A TRISUBSTRATE ANALOG FOR ALPHA(1-]3)FUCOSYLTRANSFERASE - A POTENTIAL INHIBITOR [J].

HESKAMP, BM ;

VEENEMAN, GH ;

VANDERMAREL, GA ;

VANBOECKEL, CAA ;

VANBOOM, JH .

TETRAHEDRON, 1995, 51 (30) :8397-8406

[3]

HOLMES RE, 1963, J ORG CHEM, V28, P3483, DOI 10.1021/jo01047a050

[4]

Kvasyuk EI, 1999, HELV CHIM ACTA, V82, P19

[5] Syntheses of 5′-deoxy-5′-N-hydroxylaminopyrimidine and purine nucleosides:: Building blocks for novel antisense oligonucleosides with hydroxamate linkages [J].

Li, H ;

Miller, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (25) :9289-9293

[6] ACYCLIC NUCLEOSIDE ANALOGS - METHODS FOR THE PREPARATION OF 2',3'-SECOGUANOSINE, 5'-DEOXY-2',3'-SECOGUANOSINE, AND (R,S)-9-[1-(2-HYDROXYETHOXY)-2-HYDROXYETHYL]GUANINE [J].

MCGEE, DPC ;

MARTIN, JC .

CANADIAN JOURNAL OF CHEMISTRY, 1986, 64 (09) :1885-1889

[7] USE OF AZIDO GROUP IN SYNTHESIS OF 5' TERMINAL AMINODEOXYTHYMIDINE OLIGONUCLEOTIDES [J].

MUNGALL, WS ;

GREENE, GL ;

HEAVNER, GA ;

LETSINGER, RL .

JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (11) :1659-1662

[8] 5'-AMINO-5'-DEOXYGUANOSINE AND ITS 5'-N-SUBSTITUTED DERIVATIVES - NUCLEOTIDE ANALOGS WITH P-N BOND .7. [J].

SCHATTKA, K ;

JASTORFF, B .

CHEMISCHE BERICHTE-RECUEIL, 1972, 105 (12) :3824-&

[9] NUCLEOTIDE ANALOG WITH P-N BOND .8. SYSTEMATIC INVESTIGATION OF REACTION CONDITIONS FOR PHOSPHORYLATION OF 5'-AMINO-5'-DEOXYGUANOSINE COMPOUNDS [J].

SCHATTKA, K ;

JASTORFF, B .

CHEMISCHE BERICHTE-RECUEIL, 1974, 107 (09) :3043-3052

[10] SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 8-MERCAPTOPURINE AND 6-MERCAPTOPYRIMIDINE S-NUCLEOSIDES [J].

SHUMAN, DA ;

BLOCH, A ;

ROBINS, RK ;

ROBINS, MJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (04) :653-&

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