Diurnal rhythms of free estradiol and cortisol during the normal menstrual cycle in women with major depression

被引:69
作者
Bao, AM
Ji, YF
Van Someren, EJW
Hofman, MA
Liu, RY
Zhou, JN [1 ]
机构
[1] Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Anhui Geriatr Inst, Hefei 230032, Anhui, Peoples R China
[3] Psychiat Ctr Anhui Prov, Hefei 230032, Anhui, Peoples R China
[4] Psychiat Hosp Hefei City, Hefei 230032, Anhui, Peoples R China
[5] Netherlands Inst Brain Res, NL-1105 AZ Amsterdam, Netherlands
[6] Vrije Univ Amsterdam Med Ctr, Inst Clin & Expt Neurosci, NL-1081 HV Amsterdam, Netherlands
基金
中国国家自然科学基金;
关键词
major depression; diurnal rhythm; ultradian rhythm; free estradiol; free cortisol; menstrual cycle;
D O I
10.1016/j.yhbeh.2003.09.004
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
To investigate whether depression is accompanied by changes in diurnal rhythms of free estradiol and cortisol in different phases of the menstrual cycle, we measured these two hormone levels in saliva samples collected every 2 It for 24 It from 15 healthy normally cycling women and 12 age-matched normally cycling women suffering from major depression taking antidepressants. The assessments were repeated four times over one menstrual cycle: during menstruation and in the late follicular/peri-ovulating, early to mid-luteal and late luteal phases, respectively. Quantification with a nonlinear periodic regression model revealed distinct diurnal rhythms in free estradiol and free cortisol in all subjects. For the diurnal cortisol rhythm, significant differences were found in the peak-width and ultradian amplitude among different menstrual phases, both in controls and depressed patients, while no significant differences were found between the two groups. The diurnal estradiol rhythm, on the other hand, was quite consistent among different menstrual phases within both groups, while the depressed patients had overall larger amplitudes than controls, which is negatively correlated with disease duration. Significant positive correlations between the two hormone rhythms were found for 24-h mean level (mesor, peak, and trough in late luteal phase, and for ultradian harmonics in early to mid-luteal phase in controls, but only for ultradian harmonics in late follicular/peri-ovulating phase and for acrophase in the menstruation phase in depressed patients. A sub-analysis was also performed in patients who received Fluoxetine (n = 7). The findings implicate a close correlation between the hypothalamic -pituitary - adrenal axis and the hypothalamic - pituitary - gonadal axis, both of which may be involved in depression. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:93 / 102
页数:10
相关论文
共 50 条
[1]   Diurnal rhythm of free estradiol during the menstrual cycle [J].
Bao, AM ;
Liu, RY ;
van Someren, EJW ;
Hofman, MA ;
Cao, YX ;
Zhou, JN .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (02) :227-232
[2]  
Batschelet E., 1981, CIRCULAR STAT BIOL, P169
[3]   Hypothalamic integration of central and peripheral clocks [J].
Buijs, RM ;
Kalsbeek, A .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (07) :521-526
[4]   URINARY FREE CORTISOL EXCRETION IN DEPRESSION [J].
CARROLL, BJ ;
CURTIS, GC ;
DAVIES, BM ;
MENDELS, J ;
SUGERMAN, AA .
PSYCHOLOGICAL MEDICINE, 1976, 6 (01) :43-50
[5]   POPULATION DENSITY AND REPRODUCTIVE EFFICIENCY [J].
CHRISTIAN, JJ .
BIOLOGY OF REPRODUCTION, 1971, 4 (03) :248-+
[6]   Close juxtapositions between luteinizing hormone-releasing hormone-immunoreactive neurons and corticotropin-releasing factor-immunoreactive axons in the human diencephalon [J].
Dudás, B ;
Merchenthaler, I .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (12) :5778-5784
[7]   Side of ovulation and cycle characteristics in normally fertile women [J].
Ecochard, R ;
Gougeon, A .
HUMAN REPRODUCTION, 2000, 15 (04) :752-755
[8]  
ENDO M, 1978, J CLIN PSYCHIAT, V39, P456
[9]   ENDOGENOUS OPIOID-PEPTIDES AND THE CONTROL OF THE MENSTRUAL-CYCLE [J].
FERIN, M ;
VANDEWIELE, R .
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1984, 18 (5-6) :365-373
[10]   GNRH RELEASE FROM THE MEDIOBASAL HYPOTHALAMUS - INVITRO INHIBITION BY CORTICOTROPIN-RELEASING FACTOR [J].
GAMBACCIANI, M ;
YEN, SSC ;
RASMUSSEN, DD .
NEUROENDOCRINOLOGY, 1986, 43 (04) :533-536