Plasmid DNA expression systems for the purpose of immunization

被引：64
作者：
Davis, HL
机构：
[1] Ottawa Civic Hospital, Loeb Research Institute, Ottawa, Ont. K1Y 4E9
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0958-1669(97)80041-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA vaccines induce immune responses against antigens synthesized in vivo after direct introduction of the DNA's encoding sequences. This unique approach to immunization may overcome deficits of traditional antigen-based approaches and provide safe and effective prophylactic and therapeutic vaccines. DNA vaccines are also useful as a research tool, such as for production of monoclonal antibodies. Efforts are now focusing on understanding the mechanism of antigen presentation and the adjuvant effect of immunostimulatory CpG motifs in the vectors to aid optimization of DNA vaccines.
引用
收藏
页码：635 / 640
页数：6
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