Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba

被引：32

作者：

Cheng, Zhong-Bin ^{[1
]}

Xiao, Han ^{[1
]}

Fan, Cheng-Qi ^{[2
]}

Lu, Ya-Nan ^{[2
]}

Zhang, Ge ^{[1
]}

Yin, Sheng ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

来源：

STEROIDS | 2013年 / 78卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Polyhydroxylated sterols; Structure elucidation; Antibacterial activity; Haliclona crassiloba; CORAL SINULARIA-MAYI; SOFT CORAL; SARCOPHYTON SP; SARCOSTEROL; BOND;

D O I：

10.1016/j.steroids.2013.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new polyhydroxylated sterols, named halicrasterols A-D (1-4), together with six known analogs (5-10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1-10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1-10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1353 / 1358

页数：6

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