Diagnostic and Therapeutic Potentials of microRNAs in Heart Failure

被引：15

作者：

Oikonomou, Evangelos ^{[1
]}

Siasos, Gerasimos ^{[1
]}

Tousoulis, Dimitris ^{[1
]}

Kokkou, Eleni ^{[1
]}

Genimata, Vasiliki ^{[1
]}

Zisimos, Konstantinos ^{[1
]}

Latsios, George ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Hippokration Hosp, Cardiol Dept 1, GR-11527 Athens, Greece

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 13期

关键词：

Biomarkers; heart failure; microRNA; myocardial hypertrophy; prognosis; treatment; CARDIAC-HYPERTROPHY; CARDIOMYOCYTE HYPERTROPHY; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; IN-VIVO; EXPRESSION; BIOMARKERS; DYSREGULATION; SIGNATURE; STRESS;

D O I：

10.2174/15680266113139990104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

MicroRNAs are a class of evolutionarily small non-coding RNAs of 19 to 25 nucleotides in length, that represent one of the most exciting areas of current medical science as they can regulate a complex regulatory network of gene expression and physiologic processes including differentiation, proliferation and apoptosis in a highly context dependent fashion. Recently, their role in cardiovascular disease and in the regulation of cardiomyocyte size and function, in the action potential, in angiogenesis and in mitochondrial function was recognized. Importantly, they have been evaluated for their prognostic and diagnostic role in heart failure and modification of specific microRNAs levels has been tested as a therapeutic option in experimental heart failure models. In this review article we refer the most emerging evidence, concerning the role of microRNAs in myocardial development in heart failure pathophysiology and prognosis, and their therapeutic implications.

引用

页码：1548 / 1558

页数：11

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