Macrophage phenotype-switching in cancer

被引：39
作者：
Zhang, Jiamin [1 ]
Zhou, Xiaoyan [1 ,4 ]
Hao, Hua [2 ,3 ]
机构：
[1] Nanchang Univ, Med Coll, Dept Pathophysiol, Nanchang 330006, Jiangxi, Peoples R China
[2] Tongji Univ, Yangpu Hosp, Sch Med, Dept Pathol, Shanghai 200090, Peoples R China
[3] Nanchang Univ, Med Coll, Dept Pathophysiol, 461 BaYi Rd, Nanchang 330006, Jiangxi, Peoples R China
[4] Tongji Univ, Yangpu Hosp, Sch Med, Dept Pathol, 450 Tengyue Rd, Shanghai 200090, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2022年 / 931卷
关键词：
M1; macrophage; M2; Cancer; Tumour-associated macrophages (TAMs); TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL GROWTH-FACTOR; INFILTRATING MACROPHAGES; PULMONARY METASTASIS; M-1/M-2; MACROPHAGES; KUPFFER CELLS; POLARIZATION; ANGIOGENESIS; ACTIVATION; NANOPARTICLES;
D O I：
10.1016/j.ejphar.2022.175229
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tumour-associated macrophages (TAMs) have been found to be of great importance in tumorigenesis and in promoting malignant progression, including tumour angiogenesis and metastasis. Moreover, the TAM phenotype is more likely to be an M2 type. Transforming TAMs by M2-polarization into the tumour-suppressive M1 -phenotype is an important approach for tumour therapy. In this review, we analysed the effects of the tumour microenvironment on macrophage phenotype-switching, including hypoxia and cytokines, and the mechanisms of drugs targeting TAMs. Furthermore, we analysed the effects of exosomes on macrophage polarization, phenotype switching of macrophages, and the mechanisms of lipid mediators targeting TAMs.
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页数：8
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