Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

被引：143

作者：

Chu, Derrick M. ^{[1
,2
,3
]}

Meyer, Kristen M. ^{[1
,3
,4
]}

Prince, Amanda L. ^{[1
]}

Aagaard, Kjersti M. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[2] Baylor Coll Med, Interdept Program Translat Biol & Mol Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Med Sci Training Program, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Mol & Cell Biol, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

来源：

GUT MICROBES | 2016年 / 7卷 / 06期

关键词：

DOHaD; gut microbiome gut microbiota; gut-brain axis; high-fat diet; immune development; maternal diet; obesity; pregnancy; HIGH-FAT DIET; CORONARY-HEART-DISEASE; BODY-MASS INDEX; DEVELOPMENTAL ORIGINS; INDUCED OBESITY; ORAL BACTERIA; DELIVERY MODE; BREAST-MILK; EARLY-LIFE; FETAL;

D O I：

10.1080/19490976.2016.1241357

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Evidence supporting the Developmental Origins of Health and Disease Hypothesis indicates that maternal nutrition in pregnancy has a significant impact on offspring disease risk later in life, likely by modulating developmental processes in utero. Gut microbiota have recently been explored as a potential mediating factor, as dietary components strongly influence microbiota abundance, function and its impact on host physiology. A growing body of evidence has additionally indicated that the intrauterine environment is not sterile as once presumed, indicating that maternal-fetal transmission of microbiota may occur during pregnancy. In this article, we will review the body of literature that supports this emerging hypothesis, as well as highlight the work in relevant animal models demonstrating associations with maternal gestational nutrition and the offspring gut microbiome that may influence offspring physiology and susceptibility to disease.

引用

页码：459 / 470

页数：12

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