Herpes encephalitis during natalizumab treatment in multiple sclerosis

被引：25
|
作者：
Kwiatkowski, A. [1 ]
Gallois, J. [1 ]
Bilbault, N. [1 ]
Calais, G. [1 ]
Mackowiak, A. [1 ]
Hautecoeur, P. [1 ]
机构：
[1] Univ Catholique Lille, PRES Lille Nord France, Grp Hosp, Inst Catholique Lille,Fac Libre Med,Clin Neurol, Lille, France
来源：
MULTIPLE SCLEROSIS JOURNAL | 2012年 / 18卷 / 06期
关键词：
acyclovir; encephalitis; herpes simplex; monoclonal antibody; multiple sclerosis; natalizumab; SIMPLEX ENCEPHALITIS;
D O I：
10.1177/1352458511428082
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this case report we describe the first non-fatal herpes simplex virus encephalitis (HSE) case with natalizumab for multiple sclerosis (MS). A 36-year-old woman, previously treated with immunomodulatory and immunosuppressive drugs for MS, developed acute encephalitis after 6 monthly natalizumab perfusions. Brain imaging demonstrated suggestive bi-temporal lesions. Herpes simplex virus type-1 DNA was detected in cerebrospinal fluid. The patient improved gradually after a 21-day course of intravenous acyclovir, but neuropsychiatric changes remained 5 months later. Our non-fatal case of HSE and other reported cases of herpes infections provide evidence of an increased risk with natalizumab and point to the need for clinicians to maintain awareness.
引用
收藏
页码：909 / 911
页数：3
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