Supra-amphiphilic aggregates formed by p-sulfonatocalix[4]arenes and the antipsychotic drug chlorpromazine

被引：69
|
作者：
Qin, Zhanbin [1 ]
Guo, Dong-Sheng [1 ]
Gao, Xiao-Ning [1 ]
Liu, Yu [1 ]
机构：
[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
SOFT MATTER | 2014年 / 10卷 / 13期
关键词：
WATER-SOLUBLE CALIXARENES; AQUEOUS-SOLUTION; SUPRAMOLECULAR VESICLES; SELF-ASSEMBLIES; P-SULFONATOCALIXARENE; MULTIDRUG RESISTANCE; PERSISTENT MICELLE; BINDING BEHAVIORS; SURFACTANTS; DELIVERY;
D O I：
10.1039/c3sm52866a
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We report here a supramolecular strategy to directly assemble the small molecular antipsychotic drug chlorpromazine (CPZ) into nanostructures, induced by p-sulfonatocalix[4]arene (SC4A) and p-sulfonatocalix[4] arene tetraheptyl ether (SC4AH), with high drug loading efficiencies of 61% and 46%, respectively. The binary host-guest assembly process was monitored using optical transmittance measurements, and the size and morphology of these two kinds of supra-amphiphilic assemblies were identified using a combination of light scattering and high-resolution transmission electron microscopy, which showed solid spherical micelles. This strategy presents new opportunities for the development of high loading drug-containing carriers with easy processability for drug delivery.
引用
收藏
页码：2253 / 2263
页数：11
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