Advances in the clinical application of Raman spectroscopy for cancer diagnostics

被引：140

作者：

Kallaway, Charlotte ^{[1
]}

Almond, L. Max ^{[1
]}

Barr, Hugh ^{[1
]}

Wood, James ^{[1
]}

Hutchings, Joanne ^{[1
]}

Kendall, Catherine ^{[1
]}

Stone, Nick ^{[1
]}

机构：

[1] Gloucestershire Hosp NHS Fdn Trust, Biophoton Res Unit, Gloucester GL1 3NN, England

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2013年 / 10卷 / 03期

关键词：

Raman spectroscopy; Optical; Diagnosis; Cancer; Raman probe; Multivariate analysis; Oesophagus; Colon; Breast; Urology; BREAST-CANCER; IN-VIVO; BARRETTS-ESOPHAGUS; LYMPH-NODES; IMPRINT CYTOLOGY; POTENTIAL TOOL; TISSUE; CLASSIFICATION; IDENTIFICATION; ENDOSCOPY;

D O I：

10.1016/j.pdpdt.2013.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Light interacts with tissue in a number of ways including, elastic and inelastic scattering, reflection and absorption, leading to fluorescence and phosphorescence. These interactions can be used to measure abnormal changes in tissue. Initial optical biopsy systems have potential to be used as an adjunct to current investigative techniques to improve the targeting of blind biopsy. Future prospects with molecular-specific techniques may enable objective optical detection providing a real-time, highly sensitive and specific measurement of the histological state of the tissue. Raman spectroscopy has the potential to identify markers associated with malignant change and could be used as diagnostic tool for the early detection of precancerous and cancerous lesions in vivo. The clinical requirements for an objective, non-invasive, real-time probe for the accurate and repeatable measurement of pathological state of the tissue are overwhelming. This paper discusses some of the recent advances in the field. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：207 / 219

页数：13

共 72 条

[1]

Alfano R.R., 1991, LASER LIFE SCI, V4, P23

[2] Raman spectroscopy: a potential tool for early objective diagnosis of neoplasia in the oesophagus [J].

Almond, L. Max ;

Hutchings, Joanne ;

Shepherd, Neil ;

Barr, Hugh ;

Stone, Nick ;

Kendall, Catherine .

JOURNAL OF BIOPHOTONICS, 2011, 4 (10) :685-695

[3]

Almond LM, 2011, J BIOPHOTONICS

[4]

Almond LM, 2011, J BIOMEDICAL OPTICS

[5]

[Anonymous], 2010, WALL STREET J

[6] Depth profiling of calcifications in breast tissue using picosecond Kerr-gated Raman spectroscopy [J].

Baker, Rebecca ;

Matousek, Pavel ;

Ronayne, Kate Louise ;

Parker, Anthony William ;

Rogers, Keith ;

Stone, Nicholas .

ANALYST, 2007, 132 (01) :48-53

[7] In Vivo Diagnosis of Esophageal Cancer Using Image-Guided Raman Endoscopy and Biomolecular Modeling [J].

Bergholt, M. S. ;

Zheng, W. ;

Lin, K. ;

Ho, K. Y. ;

Teh, M. ;

Yeoh, K. G. ;

So, J. B. Y. ;

Huang, Z. .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2011, 10 (02) :103-112

[8] In vivo diagnosis of gastric cancer using Raman endoscopy and ant colony optimization techniques [J].

Bergholt, Mads Sylvest ;

Zheng, Wei ;

Lin, Kan ;

Ho, Khek Yu ;

Teh, Ming ;

Yeoh, Khay Guan ;

So, Jimmy Bok Yan ;

Huang, Zhiwei .

INTERNATIONAL JOURNAL OF CANCER, 2011, 128 (11) :2673-2680

[9] Modulated Raman spectroscopy for enhanced identification of bladder tumor cells in urine samples [J].

Canetta, Elisabetta ;

Mazilu, Michael ;

De Luca, Anna Chiara ;

Carruthers, Antonia E. ;

Dholakia, Kishan ;

Neilson, Sam ;

Sargeant, Harry ;

Briscoe, Tina ;

Herrington, C. Simon ;

Riches, Andrew C. .

JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (03)

[10] Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma - A 6-year study [J].

Cox, C ;

Centeno, B ;

Dickson, D ;

Clark, J ;

Nicosia, S ;

Dupont, E ;

Greenberg, H ;

Stowell, N ;

White, L ;

Patel, J ;

Furman, B ;

Cantor, A ;

Hakam, A ;

Ahmad, N ;

Diaz, N ;

King, J .

CANCER CYTOPATHOLOGY, 2005, 105 (01) :13-20

← 1 2 3 4 5 6 7 8 →